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The role of interleukin (IL)-27 in the endogenous anti-tumour immune response and the use of an IL-27 agonist as a cancer therapeutic.

The role of interleukin (IL)-27 in the endogenous anti-tumour immune response and the use of an IL-27 agonist as a cancer therapeutic.
白细胞介素 (IL)-27 在内源性抗肿瘤免疫反应中的作用以及 IL-27 激动剂作为癌症治疗剂的用途。
批准号:
nhmrc : 1044967
负责人:
A/Pr Alexander Swarbrick
金额:
$31.6万
依托单位国家:
澳大利亚
项目类别:
Project Grants
财政年份:
2013
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2013-01-01 至 2015-12-31

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项目成果

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中文摘要
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英文摘要
Our data in mice suggest that immune cell signalling protein, interleukin (IL)-27, enhances anti-tumour immune responses and slows growth of mammary tumours and carcinogen induced sarcomas. This project aims to test how IL-27 promotes protective anti-tumour immune responses and to develop a modified IL-27 protein that will be tested as a cancer therapeutic in mice. This will be the first study to examine IL-27 function using physiological tumour models and may provide proof of concept for a new therapeutic strategy for some human cancers.
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