Dissecting the function of the Hedgehog-Patched pathway in breast cancer progression

剖析 Hedgehog-Patched 通路在乳腺癌进展中的功能

• 批准号: nhmrc : 535947
• 负责人: A/Pr Alexander Swarbrick
• 金额: $ 40.46万
• 依托单位: Garvan Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2009
• 资助国家: 澳大利亚
• 起止时间: 2009-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/dissecting-function-hedgehog-cancer-progression/100281
• 关键词: Dissecting; function; Hedgehog; Patched; pathway

There have been significant improvements in survival from breast cancer, particularly due to specialised treatments that target faulty pathways in the growth of cancer cells. One newly described, aggressive type of breast cancer called basal-like breast cancer lacks specialised treatment. We will determine whether the 'Hedgehog' signalling pathway is a suitable target for basal breast cancer therapy.

乳腺癌的生存率有了显着提高，特别是由于针对癌细胞生长中错误途径的专门治疗。一种新描述的侵袭性乳腺癌称为基底样乳腺癌，缺乏专门的治疗。我们将确定“刺猬”信号通路是否是基底乳腺癌治疗的合适靶点。