Mechanistic and functional analysis of the Id4 proto-oncogene in breast and ovarian cancer

Id4原癌基因在乳腺癌和卵巢癌中的作用机制和功能分析

• 批准号: nhmrc : 1107671
• 负责人: A/Pr Alexander Swarbrick
• 金额: $ 47.49万
• 依托单位: Garvan Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2016
• 资助国家: 澳大利亚
• 起止时间: 2016-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/mechanistic-functional-analysis-ovarian-cancer/662994
• 关键词: Mechanistic; functional; analysis; Id4; proto

Cancer arises through damage to normal regulatory processes in cells. Understanding these damaged processes is essential to implement personalized medicine. This proposal explores the role of the proto-oncogene ID4 in the closely related cancers triple negative breast cancer and serous ovarian cancer. This research may lead to the development of new therapeutic strategies or the refinement of existing strategies for these poor prognosis cancers.

癌症是通过细胞中正常调节过程的破坏而产生的。了解这些受损的过程对于实施个性化医疗至关重要。该提案探讨了原癌基因ID4在密切相关的癌症三阴性乳腺癌和浆液性卵巢癌中的作用。这项研究可能会导致新的治疗策略的发展或改善这些预后不良的癌症的现有策略。