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How does ROCK ‘education’ of fibroblasts drive neoplastic progression in the breast?

How does ROCK ‘education’ of fibroblasts drive neoplastic progression in the breast?
成纤维细胞的 ROCK“教育”如何驱动乳房肿瘤进展?
批准号:
nhmrc : 1145319
负责人:
A/Pr Alexander Swarbrick
金额:
$43.05万
依托单位国家:
澳大利亚
项目类别:
Project Grants
财政年份:
2018
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2018-01-01 至 2020-12-31

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中文摘要
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英文摘要
The spread of cancer from one part of the body to another (metastasis) is the main cause of cancer-related death. Metastasis is assisted by the abnormal behaviour of a population of cells called cancer-associated fibroblasts (CAFs). We have identified that activation of an enzyme called ROCK in breast cancers causes an increase in the number of CAFs. We plan to find out how ROCK activation causes this increase in CAFs and find new targets against which breast cancer therapies can be developed.
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Discovering new therapeutic strategies for breast cancer at cellular resolution
  • 批准号:
    nhmrc : GNT1161216
  • 项目类别:
    Research Fellowships
  • 资助金额:
    $64.92万
  • 财政年份:
    2019
  • 负责人:
    A/Pr Alexander Swarbrick
  • 依托单位:
Precision medicine for high-risk neuroblastoma
  • 批准号:
    nhmrc : GNT1146817
  • 项目类别:
    Project Grants
  • 资助金额:
    $66.0万
  • 财政年份:
    2018
  • 负责人:
    A/Pr Alexander Swarbrick
  • 依托单位:
How does ROCK ‘education’ of fibroblasts drive neoplastic progression in the breast?
  • 批准号:
    nhmrc : GNT1145319
  • 项目类别:
    Project Grants
  • 资助金额:
    $63.68万
  • 财政年份:
    2018
  • 负责人:
    A/Pr Alexander Swarbrick
  • 依托单位:
Precision medicine for high-risk neuroblastoma
  • 批准号:
    nhmrc : 1146817
  • 项目类别:
    Project Grants
  • 资助金额:
    $44.63万
  • 财政年份:
    2018
  • 负责人:
    A/Pr Alexander Swarbrick
  • 依托单位:
国内基金
海外基金
衍射光学三维信息加密与隐藏的研究
  • 批准号:
    60907004
  • 项目类别:
    青年科学基金项目
  • 资助金额:
    22.0万元
  • 批准年份:
    2009
  • 负责人:
    史祎诗
  • 依托单位: