How does ROCK ‘education’ of fibroblasts drive neoplastic progression in the breast?
How does ROCK ‘education’ of fibroblasts drive neoplastic progression in the breast?
批准号:
nhmrc : 1145319
负责人:
A/Pr Alexander Swarbrick
金额:
$43.05万
依托单位国家:
澳大利亚
项目类别:
Project Grants
财政年份:
2018
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2018-01-01 至 2020-12-31
中文摘要
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英文摘要
The spread of cancer from one part of the body to another (metastasis) is the main cause of cancer-related death. Metastasis is assisted by the abnormal behaviour of a population of cells called cancer-associated fibroblasts (CAFs). We have identified that activation of an enzyme called ROCK in breast cancers causes an increase in the number of CAFs. We plan to find out how ROCK activation causes this increase in CAFs and find new targets against which breast cancer therapies can be developed.
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会议论文
Discovering new therapeutic strategies for breast cancer at cellular resolution
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批准号:nhmrc : GNT1161216
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项目类别:Research Fellowships
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资助金额:$64.92万
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财政年份:2019
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负责人:A/Pr Alexander Swarbrick
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依托单位:
Precision medicine for high-risk neuroblastoma
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批准号:nhmrc : GNT1146817
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项目类别:Project Grants
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资助金额:$66.0万
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财政年份:2018
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负责人:A/Pr Alexander Swarbrick
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依托单位:
How does ROCK ‘education’ of fibroblasts drive neoplastic progression in the breast?
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批准号:nhmrc : GNT1145319
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项目类别:Project Grants
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资助金额:$63.68万
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财政年份:2018
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负责人:A/Pr Alexander Swarbrick
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依托单位:
Precision medicine for high-risk neuroblastoma
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批准号:nhmrc : 1146817
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项目类别:Project Grants
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资助金额:$44.63万
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财政年份:2018
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负责人:A/Pr Alexander Swarbrick
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依托单位:
Mechanistic and functional analysis of the Id4 proto-oncogene in breast and ovarian cancer
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批准号:nhmrc : 1107671
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项目类别:Project Grants
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资助金额:$47.49万
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财政年份:2016
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负责人:A/Pr Alexander Swarbrick
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依托单位:
Mechanistic and functional analysis of the Id4 proto-oncogene in breast and ovarian cancer
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批准号:nhmrc : GNT1107671
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项目类别:Project Grants
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资助金额:$69.4万
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财政年份:2016
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负责人:A/Pr Alexander Swarbrick
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依托单位:
The role of interleukin (IL)-27 in the endogenous anti-tumour immune response and the use of an IL-27 agonist as a cancer therapeutic.
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批准号:nhmrc : 1044967
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项目类别:Project Grants
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资助金额:$31.6万
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财政年份:2013
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负责人:A/Pr Alexander Swarbrick
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依托单位:
Global characterization of the Src-regulated kinome
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批准号:nhmrc : 1048550
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项目类别:Project Grants
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资助金额:$39.43万
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财政年份:2013
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负责人:A/Pr Alexander Swarbrick
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依托单位:
Dissecting the function and therapeutic potential of Hedgehog signaling in breast cancer
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批准号:nhmrc : 1051348
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项目类别:Career Development Fellowships
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资助金额:$30.62万
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财政年份:2013
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负责人:A/Pr Alexander Swarbrick
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依托单位:
Cellular and molecular mechanisms of Hedgehog signaling in breast cancer
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批准号:nhmrc : 1050693
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项目类别:Project Grants
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资助金额:$36.8万
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财政年份:2013
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负责人:A/Pr Alexander Swarbrick
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依托单位:
The Hedgehog gene as a new drug target for breast cancer
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批准号:nhmrc : GNT1051348
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项目类别:Career Development Fellowships
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资助金额:$43.99万
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财政年份:2013
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负责人:A/Pr Alexander Swarbrick
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依托单位:
Regulation of B lymphocyte survival and tumourigenesis by the TRAF2-TRAF3-cIAP signaling complex
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批准号:nhmrc : 596822
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项目类别:NHMRC Project Grants
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资助金额:$29.3万
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财政年份:2010
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负责人:A/Pr Alexander Swarbrick
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依托单位:
Dissecting the function of the Hedgehog-Patched pathway in breast cancer progression
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批准号:nhmrc : 535947
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项目类别:NHMRC Project Grants
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资助金额:$40.46万
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财政年份:2009
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负责人:A/Pr Alexander Swarbrick
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依托单位:
The role of ID-family HLH proteins in breast cancer
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批准号:nhmrc : 325646
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项目类别:Early Career Fellowships
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资助金额:$22.39万
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财政年份:2005
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负责人:A/Pr Alexander Swarbrick
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依托单位:
国内基金
海外基金
衍射光学三维信息加密与隐藏的研究
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批准号:60907004
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项目类别:青年科学基金项目
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资助金额:22.0万元
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批准年份:2009
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负责人:史祎诗
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依托单位: