How does ROCK ‘education’ of fibroblasts drive neoplastic progression in the breast?

成纤维细胞的 ROCK“教育”如何驱动乳房肿瘤进展？

• 批准号: nhmrc : 1145319
• 负责人: A/Pr Alexander Swarbrick
• 金额: $ 43.05万
• 依托单位: University of South Australia
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2018
• 资助国家: 澳大利亚
• 起止时间: 2018-01-01 至 2020-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/does-rock-education-progression-breast/1320424
• 关键词: How; does; ROCK; education; fibroblasts

The spread of cancer from one part of the body to another (metastasis) is the main cause of cancer-related death. Metastasis is assisted by the abnormal behaviour of a population of cells called cancer-associated fibroblasts (CAFs). We have identified that activation of an enzyme called ROCK in breast cancers causes an increase in the number of CAFs. We plan to find out how ROCK activation causes this increase in CAFs and find new targets against which breast cancer therapies can be developed.

癌症从身体的一部分扩散到另一部分（转移）是癌症相关死亡的主要原因。转移是由称为癌症相关成纤维细胞（CAF）的细胞群的异常行为辅助的。我们已经确定，乳腺癌中一种名为ROCK的酶的激活会导致CAF数量的增加。我们计划找出ROCK激活是如何导致CAF增加的，并找到新的靶点，以开发乳腺癌治疗方法。