Dissecting the Molecular Basis of the Malaria Parasite-Erythrocyte Tight Junction Complex

剖析疟疾寄生虫-红细胞紧密连接复合物的分子基础

• 批准号: nhmrc : 637340
• 负责人: A/Pr Stuart Ralph
• 金额: $ 36.5万
• 依托单位: The Walter and Eliza Hall Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2010
• 资助国家: 澳大利亚
• 起止时间: 2010-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/dissecting-molecular-basis-junction-complex/81579
• 关键词: Dissecting; Molecular; Basis; Malaria; Parasite

The parasites that cause malaria disease must invade the human red blood cell to complete their lifecycle. Invasion requires the formation of a complex interface between parasite and red cell called the Tight Junction. However, this structure's molecular makeup is entirely unknown. Our research will use a combination of state-of-the-art microscopy and genetics to define, for the first time, the junction's organization, providing a critical platform for the development of a malaria vaccine.

引起疟疾的寄生虫必须侵入人体红细胞才能完成其生命周期。入侵需要在寄生虫和红细胞之间形成一个复杂的界面，称为紧密连接。然而，这种结构的分子组成是完全未知的。我们的研究将使用最先进的显微镜和遗传学相结合，首次定义连接的组织，为疟疾疫苗的开发提供一个关键平台。