Metabolomic analysis of Plasmodum falciparum and mode of action of antimalarial compounds

恶性疟原虫的代谢组学分析和抗疟化合物的作用方式

• 批准号: nhmrc : 1006024
• 负责人: A/Pr Stuart Ralph
• 金额: $ 61.16万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2011
• 资助国家: 澳大利亚
• 起止时间: 2011-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/metabolomic-analysis-plasmodum-antimalarial-compounds/109138
• 关键词: Metabolomic; analysis; Plasmodum; falciparum; mode

There is an urgent need to develop new drugs to treat malaria, one of the most important diseases to afflict humanity. We have developed new analytical approaches for measuring parasite metabolism while they live inside host cells. These approaches will be used to identify metabolic pathways that are essential for parasite infectivity and to understand the mode of action of new classes of antimalarial compounds

迫切需要开发治疗疟疾的新药，疟疾是折磨人类的最重要疾病之一。我们已经开发了新的分析方法，用于测量寄生虫在宿主细胞内的代谢。这些方法将被用于确定寄生虫感染性所必需的代谢途径，并了解新型抗疟化合物的作用方式