Cytosolic and organellar tRNA synthetases in Plasmodium falciparum

恶性疟原虫胞浆和细胞器 tRNA 合成酶

• 批准号: nhmrc : 628704
• 负责人: A/Pr Stuart Ralph
• 金额: $ 28.29万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2010
• 资助国家: 澳大利亚
• 起止时间: 2010-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/cytosolic-organellar-trna-plasmodium-falciparum/100751
• 关键词: Cytosolic; organellar; tRNA; synthetases; Plasmodium

Malaria is a major worldwide infectious disease. The disease kills around 2 million people every year, and current drugs are increasingly failing due to parasite drug resistance, creating an urgent demand for new drugs, that inhibit different targets. I will study a new class of parasite drug targets, the tRNA synthetase enzymes to find novel inhibitors. Compounds blocking these enzymes may lead to new drugs to combat malaria.

疟疾是一种主要的世界性传染病。每年约有200万人死于这种疾病，由于寄生虫的耐药性，目前的药物越来越失效，这创造了对抑制不同靶点的新药的迫切需求。我将研究一类新的寄生虫药物靶点，即tRNA合成酶，以寻找新的抑制剂。阻断这些酶的化合物可能会导致抗击疟疾的新药出现。