Molecular basis of artemisinin action and resistance in Plasmodium falciparum

青蒿素作用及对恶性疟原虫耐药性的分子基础

• 批准号: nhmrc : 1139884
• 负责人: A/Pr Stuart Ralph
• 金额: $ 51.28万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2018
• 资助国家: 澳大利亚
• 起止时间: 2018-01-01 至 2021-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/molecular-basis-artemisinin-plasmodium-falciparum/1319119
• 关键词: Molecular; basis; artemisinin; action; resistance

The malaria parasite, P. falciparum causes ~450,000 deaths each year. Resistance to the front-line antimalarial drug, artemisinin, is increasing, threatening at least another 100,000 lives per year, and potentially causing an additional ~A$500M in lost productivity. This project will identify the components of the parasite's cellular defence system that underpin resistance and will point to strategies for overcoming resistance to this important drug class.

疟疾寄生虫恶性疟原虫每年造成约45万人死亡。对一线抗疟药物青蒿素的耐药性正在增加，每年至少威胁到另外10万人的生命，并可能造成额外的约5亿澳元的生产力损失。该项目将确定寄生虫细胞防御系统中支持耐药性的组成部分，并将指出克服对这一重要药物类别耐药性的战略。