Cytoskeletal remodeling of the erythrocyte during malaria parasite invasion

疟疾寄生虫入侵期间红细胞的细胞骨架重塑

• 批准号: nhmrc : 1047085
• 负责人: A/Pr Stuart Ralph
• 金额: $ 37.33万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2013
• 资助国家: 澳大利亚
• 起止时间: 2013-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/cytoskeletal-remodeling-erythrocyte-parasite-invasion/111909
• 关键词: Cytoskeletal; remodeling; erythrocyte; during; malaria

Malaria parasites cause profound human disease through infection of the red blood cell. How parasites break into the red cell is incompletely understood. Foremost, the parasite must induce radical changes in its structural integrity to enter, but to date no study has been able to precisely map these cellular events. In this research program we aim to dissect the entire process using state-of-the-art imaging, molecular biology and proteomics to shine new light on this key step in malaria disease establishment.

疟疾寄生虫通过感染红细胞引起严重的人类疾病。寄生虫是如何侵入红细胞的还不完全清楚。最重要的是，寄生虫必须诱导其结构完整性发生根本性变化才能进入，但迄今为止还没有研究能够精确地绘制这些细胞事件。在这项研究计划中，我们的目标是使用最先进的成像，分子生物学和蛋白质组学来剖析整个过程，以揭示疟疾疾病建立的这一关键步骤。