PONS IN CONTROL OF SACCADE GENERATION

控制眼跳生成的 PON

• 批准号: 6277529
• 负责人: ALBERT Frederick FUCHS
• 金额: $ 7.23万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-05-01 至 1999-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6277529
• 关键词: Mammalia; Primates; nervous system; psychology

The staging area for commands that drive motoneurons, which move the eyes, resides in the pontine and medullary reticular formations of the brainstem. When the head is prevented from turning, rapid eye movements, called saccades, shift the direction of gaze with the help of brainstem neurons that discharge a burst of action potentials. These burst neurons are held in check by inhibition from neurons that usually fire steadily but cease firing or pause with all saccades. During the past year we investigated whether, when the head is free to turn and a gaze shift is composed of an eye and a head movement, the pause of these omnipause neurons (OPNs) is still best correlated with eye movement or instead controls head duration or the duration of the overall gaze shift, i.e., eye position + head position. We found that pause duration was poorly correlated with head duration. Moreover, by correlating pause duration with movement duration, we could not ascertain whether pause duration was better correlated with eye or overall gaze duration. However, when we aligned the end of the pause with the end of the saccade, the pause was almost always better aligned with the end of the eye movement than the end of the gaze movement. Therefore, we conclude that the OPNs, which lie in the pons, are involved with the eye component of a gaze shift and not with the overall gaze shift nor the head movement component. In contrast, the firing patterns of various of the aforementioned burst neurons may be better correlated with either the eye movement, the gaze movement, or the overall gaze shift. Pause and burst neurons with these characteristics fit nicely into our model for a separate control of eye and head movements during a gaze shift.

运动神经元的运动指令 眼睛，位于脑桥和延髓网状结构中， 脑干 当头部被阻止转动时，快速眼 这种称为扫视的运动， 脑干神经元释放出一系列动作电位。 这些爆发神经元受到来自神经元的抑制， 通常稳定地发射，但在所有扫视时停止发射或暂停。 在过去的一年里，我们调查了是否，当头部是免费的， 转动和注视转移由眼睛和头部运动组成， 这些全间歇神经元（OPN）的停顿仍然与 眼睛运动或相反地控制头部持续时间或 总的注视移动，即，眼睛位置+头部位置。 我们发现 停顿持续时间与头部持续时间相关性较差。 此外，由 将停顿持续时间与运动持续时间相关联，我们无法 确定停顿持续时间是否与眼睛或 整体凝视时间。 然而，当我们将停顿的结尾对齐时， 在扫视结束时，停顿几乎总是更好， 与眼球运动的结束对齐，而不是凝视的结束 运动 因此，我们得出结论，OPN，这是在 脑桥与凝视转移的眼睛成分有关，而与 整体的注视移动也没有头部移动分量。 与此相反， 各种上述突发神经元的激发模式可以 更好地与眼球运动，凝视运动， 或整体的视线转移。 神经元的分裂和爆裂 特征很好地适合我们的模型，用于单独控制 凝视转移期间的眼睛和头部运动。