STUDY OF SOCIAL AND COGNITIVE ASPECTS OF SCHIZOPHRENICS

精神分裂症患者的社会和认知方面的研究

• 批准号: 6290511
• 负责人: Carmi Schooler
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF MENTAL HEALTH
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6290511
• 关键词: brain disorders; clinical research; cognition disorders; frontal lobe /cortex; human subject; interview; memory; psychopharmacology; schizophrenia; smooth pursuit eye movement; social behavior disorders

This project uses experimental psychological techniques to examine whether schizophrenic deficits in ocular-motor, cognitive and social tasks result from an impaired ability to suppress inappropriate responses linked to dysfunction of the prefrontal cortex and related brain areas. Data collection from our core sample of 65 medicated schizophrenics and 44 matched normals is complete. We are, however, continuing to test subjects available in both a medicated and a drug free state. In order to elucidate the nature of the psychological effects of pharmacological treatments and to explore differences between typical and atypical neuroleptics, we have developed some new experimental procedures that finely examine the temporal dimensions of selective attention and negative priming. We have also modified for use by schizophrenic subjects new experimental measure of working memory and negative priming. In addition, we continued the tasks of preparing our data for analysis and carrying out analyses of already prepared data. This year we paid particular attention to the complex issues involved in eye-movement measurement. The data from these experiments together with other data we have collected on the same subjects raise the possibility of a particular memory deficit in schizophrenic individuals in the 50 to 150 ms range. If this is the case, it would also suggests that schizophrenics may not experience reality as a continuous flow. - Schizophrenic, ocular-motor, cognitive, working memory - Human Subjects: Interview, Questionaires, or Surveys Only

该项目使用实验心理学技术来检查精神分裂症在眼球运动、认知和社交任务中的缺陷是否是由于抑制与前额叶皮质和相关脑区功能障碍有关的不适当反应的能力受损所致。我们从65名药物精神分裂症患者和44名匹配的正常人的核心样本中收集的数据已经完成。然而，我们正在继续测试有药和无药两种状态的受试者。为了阐明药物治疗的心理效应的本质，并探索典型和非典型抗精神病药物之间的差异，我们开发了一些新的实验程序，精细地检查了选择性注意和负启动的时间维度。我们还修改了新的工作记忆和负启动实验测量方法，供精神分裂症受试者使用。此外，我们继续为分析准备数据，并对已经准备好的数据进行分析。今年，我们特别关注眼动测量中涉及的复杂问题。这些实验的数据，加上我们在相同受试者上收集的其他数据，增加了精神分裂症患者在50到150毫秒范围内出现特定记忆缺陷的可能性。如果是这样的话，这也表明精神分裂症患者可能不会连续地体验到现实。-精神分裂症、眼球运动、认知、工作记忆-人类受试者：仅采访、问卷或调查