鸡蛋中蛋白质生产的通用接受者-猫眼课题宝

鸡蛋中蛋白质生产的通用接受者

批准号：

6403315

负责人：

BABETTE S HEYER

金额：

$10.0万

依托单位：

ORIGEN THERAPEUTICS

依托单位国家：

美国

项目类别：

财政年份：

2001

资助国家：

美国

项目状态：

已结题

起止时间：

2001-09-01 至 2002-08-31

来源：

https://reporter.nih.gov/project-details/6403315

关键词：

biological products bioreactors biotechnology biotherapeutic agent chickens egg /ovum genetic promoter element genetically modified animals method development molecular cloning protein biosynthesis recombinant proteins

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英文摘要

DESCRIPTION (provided by applicant): To date, chimeric chickens are made by injecting blastodermal cells or embryonic stem cells into the stage X embryo (recipient), but the frequency and the level of chimerism is variable and unpredictable. We plan to develop a universal recipient that contributes minimally, so that the contribution of donor derived cells to the resulting chimera is constantly high and predictable. Somatic chimeras can be used to produce biopharmaceutical proteins in eggs as soon as the chimeras commence laying and before they transmit the gene encoding the biopharmaceutical protein to the next generation. PROPOSED COMMERCIAL APPLICATION: NOT AVAILABLE

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