An universal recipient for protein production in eggs

鸡蛋中蛋白质生产的通用接受者

• 批准号: 6606415
• 负责人: BABETTE S HEYER
• 金额: $ 2.71万
• 依托单位: ORIGEN THERAPEUTICS
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-09-01 至 2002-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6606415
• 关键词: biological products; bioreactors; biotechnology; biotherapeutic agent; chickens; egg /ovum; genetic promoter element; genetically modified animals; method development; molecular cloning; protein biosynthesis; recombinant proteins

DESCRIPTION (provided by applicant): To date, chimeric chickens are made by injecting blastodermal cells or embryonic stem cells into the stage X embryo (recipient), but the frequency and the level of chimerism is variable and unpredictable. We plan to develop a universal recipient that contributes minimally, so that the contribution of donor derived cells to the resulting chimera is constantly high and predictable. Somatic chimeras can be used to produce biopharmaceutical proteins in eggs as soon as the chimeras commence laying and before they transmit the gene encoding the biopharmaceutical protein to the next generation. PROPOSED COMMERCIAL APPLICATION: NOT AVAILABLE

描述(申请人提供)：迄今为止，嵌合体鸡由 将囊胚层细胞或胚胎干细胞注射到X期胚胎 (接受者)，但嵌合体的频率和水平是可变的 变幻莫测。我们计划开发一个捐款最少的通用接受者， 因此，供体来源的细胞对所产生的嵌合体的贡献是持续的 高度和可预见性。体细胞嵌合体可用于生产生物制药 嵌合体一开始产卵，在它们传播之前，卵中的蛋白质 编码生物药用蛋白质的基因传给下一代。 建议的商业应用：不可用