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PNEUMOCYSITIS CARINII INFECTION THERAPIES--PRECLIN EVAL

PNEUMOCYSITIS CARINII INFECTION THERAPIES--PRECLIN EVAL
卡氏肺囊虫感染治疗 - PRECLIN 评估
批准号：
6334487
负责人：
PETER D WALZER
金额：
$33.61万
依托单位：
UNIVERSITY OF CINCINNATI
依托单位国家：
美国
项目类别：
财政年份：
1997
资助国家：
美国
项目状态：
已结题
起止时间：
1997-09-01 至 2002-08-31
来源：
https://reporter.nih.gov/project-details/6334487
关键词：
Pneumocystis carinii antibacterial agents chemoprevention drug screening /evaluation laboratory mouse laboratory rat nonhuman therapy evaluation respiratory disorder chemotherapy tissue /cell culture

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中文摘要
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英文摘要
The overall objective of this contract is to facilitate discovery and development of therapies with potential for treatment and prophylaxis of Pneumocystis carinii pneumonia in people with AIDS. The expected performance of this contract is to quantitatively evaluate therapeutic agents for efficacy against Pneumocystis carinii pneumonia in a standardized, validated mouse model test system, to include evaluation of therapies in combination in the primary mouse model, drug evaluations in prophylaxis protocols in the primary mouse model, and evaluation of treatment therapies in a rat model. Therapeutic agents will be evaluated for activity in a standardized, reproducible and validated in vitro (culture) test system which employs intact organisms.
期刊论文(8)
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科研奖励(0)
会议论文
Standardization of an in vitro drug screening assay by use of cryopreserved and characterized Pneumocystis carinii populations.
使用冷冻保存和特征化的卡氏肺囊虫群体进行体外药物筛选测定的标准化。
DOI： 10.1111/j.1550-7408.2001.tb00509.x
发表时间： 2001
期刊： The Journal of eukaryotic microbiology
影响因子： --
作者： [Collins,MS, Cushion,MT]
通讯作者： Cushion,MT
Echinocandin treatment of pneumocystis pneumonia in rodent models depletes cysts leaving trophic burdens that cannot transmit the infection.
DOI： 10.1371/journal.pone.0008524
发表时间： 2010-01-29
期刊： PloS one
影响因子： 3.7
作者： [Cushion MT, Linke MJ, Ashbaugh A, Sesterhenn T, Collins MS, Lynch K, Brubaker R, Walzer PD]
通讯作者： Walzer PD
Sequence of the mitochondrial genome of Pneumocystis carinii: implications for biological function and identification of potential drug targets.
卡氏肺孢子虫线粒体基因组序列：对生物功能和潜在药物靶标识别的影响。
DOI： 10.1111/j.1550-7408.2006.00212.x
发表时间： 2006
期刊： The Journal of eukaryotic microbiology
影响因子： --
作者： [Sesterhenn,ThomasM, Cushion,MelanieT, Slaven,BradleyE, Smulian,AGeorge]
通讯作者： Smulian,AGeorge
Serum Antibodies to Recombinant Pneumocystis Antigens
  • 批准号：
    7188525
  • 项目类别：
  • 资助金额：
    $45.08万
  • 财政年份：
    2005
  • 负责人：
    PETER D WALZER
  • 依托单位：
    UNIVERSITY OF CINCINNATI
Serum Antibodies to Recombinant Pneumocystis Antigens
  • 批准号：
    7585265
  • 项目类别：
  • 资助金额：
    $46.77万
  • 财政年份：
    2005
  • 负责人：
    PETER D WALZER
  • 依托单位：
    UNIVERSITY OF CINCINNATI
Global Serological Study of Pneumocystis Infection
Global Serological Study of Pneumocystis Infection
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