PNEUMOCYSITIS CARINII INFECTION THERAPIES--PRECLIN EVAL

卡氏肺囊虫感染治疗 - PRECLIN 评估

• 批准号: 6334487
• 负责人: PETER D WALZER
• 金额: $ 33.61万
• 依托单位: UNIVERSITY OF CINCINNATI
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-09-01 至 2002-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6334487
• 关键词: Pneumocystis carinii; antibacterial agents; chemoprevention; drug screening /evaluation; laboratory mouse; laboratory rat; nonhuman therapy evaluation; respiratory disorder chemotherapy; tissue /cell culture

The overall objective of this contract is to facilitate discovery and development of therapies with potential for treatment and prophylaxis of Pneumocystis carinii pneumonia in people with AIDS. The expected performance of this contract is to quantitatively evaluate therapeutic agents for efficacy against Pneumocystis carinii pneumonia in a standardized, validated mouse model test system, to include evaluation of therapies in combination in the primary mouse model, drug evaluations in prophylaxis protocols in the primary mouse model, and evaluation of treatment therapies in a rat model. Therapeutic agents will be evaluated for activity in a standardized, reproducible and validated in vitro (culture) test system which employs intact organisms.

本合同的总体目标是促进发现和 开发具有治疗和预防潜力的疗法 卡氏肺孢子虫肺炎的发病率 本合同的预期性能是定量评估 对卡氏肺孢子虫肺炎有效的治疗剂 在标准化的、经验证的小鼠模型测试系统中，包括 在初级小鼠模型中联合治疗的评价， 在初级小鼠模型中预防方案中的药物评价， 以及在大鼠模型中评价治疗疗法。 治疗 将以标准化的、可重复的方法评价试剂的活性。 并验证了体外（培养）试验系统， 有机体

项目成果

Standardization of an in vitro drug screening assay by use of cryopreserved and characterized Pneumocystis carinii populations.

使用冷冻保存和特征化的卡氏肺囊虫群体进行体外药物筛选测定的标准化。

• DOI: 10.1111/j.1550-7408.2001.tb00509.x
• 发表时间: 2001
• 期刊: The Journal of eukaryotic microbiology
• 作者: Collins,MS;Cushion,MT
• 通讯作者: Cushion,MT

Echinocandin treatment of pneumocystis pneumonia in rodent models depletes cysts leaving trophic burdens that cannot transmit the infection.

• DOI: 10.1371/journal.pone.0008524
• 发表时间: 2010-01-29
• 期刊: PloS one
• 影响因子: 3.7
• 作者: Cushion MT;Linke MJ;Ashbaugh A;Sesterhenn T;Collins MS;Lynch K;Brubaker R;Walzer PD
• 通讯作者: Walzer PD

Sequence of the mitochondrial genome of Pneumocystis carinii: implications for biological function and identification of potential drug targets.

卡氏肺孢子虫线粒体基因组序列：对生物功能和潜在药物靶标识别的影响。

• DOI: 10.1111/j.1550-7408.2006.00212.x
• 发表时间: 2006
• 期刊: The Journal of eukaryotic microbiology
• 作者: Sesterhenn,ThomasM;Cushion,MelanieT;Slaven,BradleyE;Smulian,AGeorge
• 通讯作者: Smulian,AGeorge