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STUDY OF PROTEOLYTICDEGRADATION OF P-AMYLOID PROTEIN (AD)

STUDY OF PROTEOLYTICDEGRADATION OF P-AMYLOID PROTEIN (AD)
P-淀粉样蛋白(AD)的蛋白水解降解研究
批准号：
6307551
负责人：
Rong Wang
金额：
$0.82万
依托单位：
ROCKEFELLER UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
1999
资助国家：
美国
项目状态：
已结题
起止时间：
1999-12-01 至 2000-11-30
来源：
https://reporter.nih.gov/project-details/6307551
关键词：
biomedical resource human tissue mental disorders spectrometry

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中文摘要
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英文摘要
Affinity MS is being used extensively in a detailed series of studies concerning proteolytic degradation of P-amyloid protein AD). In particular, the new approach is being used to help: Identify proteolytic fragments of AD in cultured cells. Measure degradation rates for AD 1 -40 and A P 1 -42. Characterize proteolytic enzymes involved in AD degradation. Examine pH dependency of proteolytic degradation of AD. Correlate proteolytic AD degradation and AD peptide composition in Alzheimer's disease patient's brain.
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