GENOMIC DATABASE FOR THE YEAST SACCHAROMYCES

酵母基因组数据库

• 批准号: 6181622
• 负责人: DAVID BOTSTEIN
• 金额: $ 151.58万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1995
• 资助国家: 美国
• 起止时间: 1995-09-30 至 2001-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6181622
• 关键词: DNA; Internet; Saccharomyces cerevisiae; biomedical resource; biotechnology; computer assisted sequence analysis; computer network; computer program /software; computer system design /evaluation; fungal genetics; gene mutation; genetic mapping; information retrieval; linkage mapping; molecular biology information system; nucleic acid sequence

The goals of this project are to design, implement, and make generally available a database containing correlated information about the genome of budding yeast (Saccharomyces cerevisiae). The database consists of four central elements: the genetic map, the physical map, the DNA sequence, and biological information (mainly summaries of what is known about the functions of the genes, their products, their interactions and supporting bibliographic references for all of the above). These data have been assimilated into SacchDB, using the ACEDB genomic database software (both a UNIX and a Macintosh version are fully supported) and into the Nucleus Server, an on-line system of our own design that allows very fast responses to simple map-based queries over the Internet. The Saccharomyces Genome Database (SGD) staff will, under this program, maintain, disseminate, update and enhance the database, providing access by CD-ROM, Gopher, Anonymous FTP, and World Wide Web (WWW) as well as the Nucleus server through a Macintosh client and a gateway to Gopher. It is anticipated that the sequence of the entire genome of Saccharomyces cerevisiae will be available some time in 1997. The expectation is that the SGD will be a suitable comprehensive genome database by that time so that the genome research community and the broader biomedical research community can obtain the maximum benefit from having the first complete sequence of a eukaryotic genome.

本项目的目标是设计、实施和制作通用的 一个包含基因组相关信息的数据库 芽殖酵母（Saccharomyces cerevisiae）该数据库包括 四个核心要素：基因图谱，物理图谱，DNA 序列和生物信息（主要是已知信息的摘要 基因的功能，它们的产物，它们之间的相互作用， 支持上述所有内容的参考书目）。 这些数据已被吸收到SacchDB中，使用ACEDB基因组 数据库软件（UNIX和Macintosh版本都完全 支持），并进入Nucleus服务器，我们自己的在线系统 设计允许非常快速地响应简单的基于地图的查询， 互联网酵母基因组数据库（SGD）的工作人员将根据 该方案，维护，传播，更新和加强数据库， 通过CD-ROM、Gopher、匿名FTP和万维网提供访问 (WWW)以及通过Macintosh客户端和 Gopher的入口 预计酵母菌的整个基因组的序列 酿酒厂将于1997年某个时候上市。人们期望 到那时，SGD将成为一个合适综合基因组数据库，因此 基因组研究团体和更广泛的生物医学研究 社区可以从第一个完成的项目中获得最大的利益， 真核生物基因组的序列。