Quantitative and Computational Biology Graduate Program

描述（由申请人提供）：普林斯顿大学要求支持一个新的基因组学多学科培训项目，旨在为基因组科学家提供未来生物学可能需要的定量和计算工具。基因组培训计划将支持普林斯顿大学新的定量与计算生物学研究生项目（QCB）的学生，该项目是由新的Lewis-Sigler整合基因组学研究所和普林斯顿大学的四个部门（计算机科学、生态与进化生物学、分子生物学和物理学）联合开展的，由该研究所管理。基因组学学员将能够与QCB 10个系的54名教师中的任何一名进行论文研究，这些系在定量生物学和计算生物学方面有着共同的兴趣。第一年需要5个基因组学培训名额，第二年需要10个，之后每年需要15个，这样就可以支持15个基因组学培训名额的稳定人口。除了满足其中一个参与部门的要求外，基因组学学员将在细菌，真核模型和哺乳动物系统的各种功能基因组学项目中进行研究；从基础生物信息学和分子进化到高通量数据可视化的计算项目；从微生物代谢到系统神经科学的系统生物学项目；生物物理项目，从基础结构生物学到新蛋白质和调控开关的构建；理论项目范围从基本的动力学建模到试图模拟上皮细胞或神经元的信号转导。受训者将有一个由QCB执行委员会和基因组学委员会管理的个性化培训计划；正式培训将包括基因组学和基因组分析的新课程、系列研讨会、学生经营的期刊俱乐部以及以研究所为中心的其他多学科活动。受训者将有机会在普林斯顿大学为本科生开设的一个创新的多学科入门课程中授课。最后，受训者和合格的教员将参加一些活动，这些活动旨在招募和教授代表性不足的少数民族成员，并将基因组学的信息扩展到高中教师。

DESCRIPTION (provided by applicant): Support is requested for a new multi-disciplinary training program in genomics at Princeton University, aimed at educating genome scientists with the quantitative and computational tools likely to be required for the biology of the future. The genome training program will support students in Princeton's new Graduate Program in Quantitative and computational Biology (QCB), a joint undertaking between the new Lewis-Sigler Institute for Integrative Genomics and four Princeton departments (Computer Science, Ecology and Evolutionary Biology, Molecular Biology, and Physics) and administered by the Institute. Genomics trainees will be able to do their thesis research with any of 54 QCB faculty in 10 departments united by common interests in quantitative and computational biology. Five genomics training slots are requested for the first year, 10 for the second, and 15 for each year thereafter, so that a steady-state population of 15 genomics trainees can be supported. In addition to fulfilling the requirements of one of the participating departments, genomics trainees will do research in any of a wide array of functional genomics projects in bacteria, eukaryotic models and mammalian systems; computational projects ranging from basic bio-informatics and molecular evolution to high-throughput data visualization; systems biology projects ranging from microbial metabolism to systems neuroscience; biophysical projects from basic structural biology to the construction of novel proteins and regulatory switches; and theoretical projects ranging from basic dynamical modeling to trying to model signal transduction in epithelia or neurons. Trainees will have an individualized training plan administered by the Executive Committee of the QCB and a Genomics Committee; formal training will include new courses in genomics and genomic analysis, a seminar series, a student-run journal club, and other multi-disciplinary activities centered in the Institute. Trainees will have the opportunity to teach in an innovative new multidisciplinary introductory program for undergraduates at Princeton. Finally, trainees and eligible faculty will participate in a number of activities designed to recruit and teach individuals who are members of under-represented minorities, and to extend the genomics message to high school teachers.