Quantitavie and Computational Biology Graduate Program

描述（由申请人提供）：现申请普林斯顿大学基因组学多学科培训项目的更新支持，该项目旨在培养基因组科学家，使其具备未来生物学可能需要的定量和计算工具。基因组培训计划将支持普林斯顿大学定量与计算生物学研究生项目（QCB）的学生，该项目是刘易斯-西格勒综合基因组学研究所和普林斯顿大学五个系（计算机科学、生态与进化生物学、分子生物学、化学与物理）的联合项目，由该研究所管理。基因组学学员将能够与QCB 10个系的49名教师中的任何一名进行论文研究，这些系在定量生物学和计算生物学方面有着共同的兴趣。学员将研究细菌、真核生物模型和哺乳动物系统的功能基因组学；从生物信息学和分子进化到高通量数据可视化的计算项目和从微生物代谢到系统神经科学的系统生物学项目；理论项目范围从基本的动力学建模到模拟上皮细胞或神经元的信号转导。由于培训计划在获得培训补助金时完全是全新的，并且仍在增长，而且它仍然是为数不多的培训计划之一，因此我们要求从9个职位（目前的水平）适度增加，每年增加一个职位，以达到12个职位的新稳定状态。受训者将有一个由QCB执行委员会和基因组学委员会管理的个性化培训计划；正式培训将包括基因组学和基因组分析的新课程、系列研讨会、学生经营的期刊俱乐部以及以研究所为中心的其他多学科活动。受训者将有机会在普林斯顿大学为本科生开设的一个创新的多学科入门课程中任教。最后，受训者和合格的教员将参加一些活动，这些活动的目的是征聘和教授代表人数不足的少数群体的个人。

DESCRIPTION (provided by applicant): Support is requested for a renewal of a multi-disciplinary training program in genomics at Princeton, aimed at educating genome scientists with the quantitative and computational tools likely to be required for the biology of the future. The genome training program will support students in Princeton's Graduate Program in Quantitative and Computational Biology (QCB), a joint undertaking between the Lewis-Sigler Institute for Integrative Genomics and five Princeton departments (Computer Science, Ecology and Evolutionary Biology, Molecular Biology, Chemistry and Physics) and administered by the Institute. Genomics trainees will be able to do their thesis research with any of 49 QCB faculty in 10 departments united by common interests in quantitative and computational biology. Trainees will do research in functional genomics in bacteria, eukaryotic models and mammalian systems; computational projects ranging from bio-informatics and molecular evolution to high-throughput data visualization and systems biology projects ranging from microbial metabolism to systems neuroscience; and theoretical projects ranging from basic dynamical modeling to modeling signal transduction in epithelia or neurons. Because the training program, completely new when the training grant was awarded, is still growing, and because it is still one of the few of its kind, we request a modest increase from 9 positions (the current level), ramping up one position per year to a new steady state of 12 slots. Trainees will have an individualized training plan administered by the Executive Committee of the QCB and a Genomics Committee; formal training will include new courses in genomics and genomic analysis, a seminar series, a student-run journal club, and other multi-disciplinary activities centered in the Institute. Trainees will have the opportunity to teach in a new innovative multidisciplinary introductory program for undergraduates at Princeton. Finally, trainees and eligible faculty will participate in a number of activities designed to recruit and teach individuals who are members of under-represented minority groups. PUBLIC HEALTH RELEVANCE: The genome and the computer have revolutionized biomedical science. In order that the medical science of the future takes full advantage of this revolution, a new kind of education for Ph.D. biomedical scientists is required, one in which biology and the more quantitative sciences, especially computation, are given equal weight. The NHGRI training program at Princeton is one of the pioneer programs fulfilling this role.