Quantitavie and Computational Biology Graduate Program

描述(由申请者提供)：申请支持普林斯顿大学基因组学多学科培训计划的更新，旨在教育基因组科学家掌握未来生物学可能需要的定量和计算工具。基因组培训计划将支持普林斯顿定量和计算生物学研究生项目(QCB)的学生，该项目是刘易斯-西格勒整合基因组研究所和普林斯顿大学五个系(计算机科学、生态学和进化生物学、分子生物学、化学和物理学)的联合项目，由该研究所管理。基因组学实习生将能够与10个系的49名QCB教员中的任何人一起进行论文研究，这些教员因对定量和计算生物学的共同兴趣而团结在一起。学员将从事细菌、真核模型和哺乳动物系统的功能基因组学研究；从生物信息学和分子进化到高通量数据可视化的计算项目和从微生物新陈代谢到系统神经科学的系统生物学项目；以及从基本动力学建模到建模上皮或神经元的信号转导的理论项目。由于培训计划在授予培训补助金时是全新的，而且仍是为数不多的此类培训计划之一，我们要求适度增加9个职位(目前的水平)，将每年一个职位增加到12个职位的新稳定状态。受训者将有一个由QCB执行委员会和基因组学委员会管理的个性化培训计划；正式培训将包括基因组学和基因组分析方面的新课程、一系列研讨会、学生开办的期刊俱乐部，以及以研究所为中心的其他多学科活动。受训者将有机会在普林斯顿大学为本科生开设的创新的多学科入门课程中任教。最后，受训者和合格的教职员工将参加一些旨在招募和教授代表不足的少数群体成员的活动。 与公共健康相关：基因组和计算机已经彻底改变了生物医学科学。为了让未来的医学充分利用这场革命，需要对生物医学博士科学家进行一种新的教育，在这种教育中，生物学和更多的定量科学，特别是计算，得到同等的重视。普林斯顿的NHGRI培训项目是履行这一角色的先驱项目之一。

DESCRIPTION (provided by applicant): Support is requested for a renewal of a multi-disciplinary training program in genomics at Princeton, aimed at educating genome scientists with the quantitative and computational tools likely to be required for the biology of the future. The genome training program will support students in Princeton's Graduate Program in Quantitative and Computational Biology (QCB), a joint undertaking between the Lewis-Sigler Institute for Integrative Genomics and five Princeton departments (Computer Science, Ecology and Evolutionary Biology, Molecular Biology, Chemistry and Physics) and administered by the Institute. Genomics trainees will be able to do their thesis research with any of 49 QCB faculty in 10 departments united by common interests in quantitative and computational biology. Trainees will do research in functional genomics in bacteria, eukaryotic models and mammalian systems; computational projects ranging from bio-informatics and molecular evolution to high-throughput data visualization and systems biology projects ranging from microbial metabolism to systems neuroscience; and theoretical projects ranging from basic dynamical modeling to modeling signal transduction in epithelia or neurons. Because the training program, completely new when the training grant was awarded, is still growing, and because it is still one of the few of its kind, we request a modest increase from 9 positions (the current level), ramping up one position per year to a new steady state of 12 slots. Trainees will have an individualized training plan administered by the Executive Committee of the QCB and a Genomics Committee; formal training will include new courses in genomics and genomic analysis, a seminar series, a student-run journal club, and other multi-disciplinary activities centered in the Institute. Trainees will have the opportunity to teach in a new innovative multidisciplinary introductory program for undergraduates at Princeton. Finally, trainees and eligible faculty will participate in a number of activities designed to recruit and teach individuals who are members of under-represented minority groups. PUBLIC HEALTH RELEVANCE: The genome and the computer have revolutionized biomedical science. In order that the medical science of the future takes full advantage of this revolution, a new kind of education for Ph.D. biomedical scientists is required, one in which biology and the more quantitative sciences, especially computation, are given equal weight. The NHGRI training program at Princeton is one of the pioneer programs fulfilling this role.