Quantitavie and Computational Biology Graduate Program

描述（由申请人提供）：请求支持普林斯顿大学基因组学多学科培训计划的更新，旨在教育基因组科学家使用未来生物学可能需要的定量和计算工具。基因组训练计划将支持学生在普林斯顿大学的研究生课程在定量和计算生物学（QCB），刘易斯-西格勒研究所之间的综合基因组学和五个普林斯顿部门（计算机科学，生态学和进化生物学，分子生物学，化学和物理学）的联合事业，并由该研究所管理。基因组学的学员将能够做他们的论文研究与任何49 QCB教师在10个部门的共同利益团结在定量和计算生物学。学员将在细菌，真核生物模型和哺乳动物系统中进行功能基因组学研究;计算项目，从生物信息学和分子进化到高通量数据可视化和系统生物学项目，从微生物代谢到系统神经科学;以及理论项目，从基础动力学建模到上皮细胞或神经元中的信号转导建模。由于培训计划在获得培训补助金时是全新的，仍在增长，而且由于它仍然是为数不多的同类项目之一，我们要求从9个职位（目前的水平）适度增加，每年增加一个职位，达到12个职位的新稳定状态。学员将有一个个性化的培训计划，由QCB的执行委员会和基因组学委员会管理;正式的培训将包括基因组学和基因组学分析的新课程，系列研讨会，学生运行的期刊俱乐部，以及其他以研究所为中心的多学科活动。学员将有机会在普林斯顿大学为本科生开设的一个新的创新多学科介绍课程中授课。最后，受训人员和符合条件的教员将参加一些活动，这些活动的目的是招聘和教授代表性不足的少数群体成员。 公共卫生相关性：基因组和计算机彻底改变了生物医学科学。为了使未来的医学科学充分利用这一革命，一种新的博士教育，生物医学科学家是必需的，其中生物学和更多的定量科学，特别是计算，给予同等的重视。普林斯顿大学的NHGRI培训计划是履行这一角色的先驱计划之一。

DESCRIPTION (provided by applicant): Support is requested for a renewal of a multi-disciplinary training program in genomics at Princeton, aimed at educating genome scientists with the quantitative and computational tools likely to be required for the biology of the future. The genome training program will support students in Princeton's Graduate Program in Quantitative and Computational Biology (QCB), a joint undertaking between the Lewis-Sigler Institute for Integrative Genomics and five Princeton departments (Computer Science, Ecology and Evolutionary Biology, Molecular Biology, Chemistry and Physics) and administered by the Institute. Genomics trainees will be able to do their thesis research with any of 49 QCB faculty in 10 departments united by common interests in quantitative and computational biology. Trainees will do research in functional genomics in bacteria, eukaryotic models and mammalian systems; computational projects ranging from bio-informatics and molecular evolution to high-throughput data visualization and systems biology projects ranging from microbial metabolism to systems neuroscience; and theoretical projects ranging from basic dynamical modeling to modeling signal transduction in epithelia or neurons. Because the training program, completely new when the training grant was awarded, is still growing, and because it is still one of the few of its kind, we request a modest increase from 9 positions (the current level), ramping up one position per year to a new steady state of 12 slots. Trainees will have an individualized training plan administered by the Executive Committee of the QCB and a Genomics Committee; formal training will include new courses in genomics and genomic analysis, a seminar series, a student-run journal club, and other multi-disciplinary activities centered in the Institute. Trainees will have the opportunity to teach in a new innovative multidisciplinary introductory program for undergraduates at Princeton. Finally, trainees and eligible faculty will participate in a number of activities designed to recruit and teach individuals who are members of under-represented minority groups. PUBLIC HEALTH RELEVANCE: The genome and the computer have revolutionized biomedical science. In order that the medical science of the future takes full advantage of this revolution, a new kind of education for Ph.D. biomedical scientists is required, one in which biology and the more quantitative sciences, especially computation, are given equal weight. The NHGRI training program at Princeton is one of the pioneer programs fulfilling this role.