Integrating and Disseminating Functional Genomics Data

整合和传播功能基因组数据

• 批准号: 7022243
• 负责人: DAVID BOTSTEIN
• 金额: $ 55.53万
• 依托单位: PRINCETON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-03-01 至 2008-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7022243
• 关键词: Saccharomyces cerevisiae; bioinformatics; biotechnology; functional /structural genomics; fungal genetics; information dissemination; technology /technique development

DESCRIPTION (provided by applicant): The explosion of genome-wide research over the last decade has made clear the need for a new paradigm for the way in which biological information is integrated and disseminated to the research community. Thus, the overall goal of this proposal is to devise and implement systems that make possible continuing integration of the information contained within genomic data sets, including, at a minimum, gene expression, 2-hybrid, synthetic lethality, and systematic deletion studies, and to make the integrated information accessible to the research community, initially through the Saccharomyces Genome Database (SGD), and later through other model organism databases as we create a generally applicable system and submit it to the Generic Model Organism Database (GMOD) project. We envision that information from the data sets will become accessible through 2 general routes: first, the data integration system will be a guide to curators in assessing what is known about the function of genes, especially those genes for which little is known; second, we will organize the integrated data, on a continuing basis, into a schema that can be queried directly. By providing multiple sources of information and the tools to integrate and query them in new and better ways, we aim to help biologists progress toward seeing individual genes or pathways of interest in a more global context. Equally important, we hope to add to our knowledge of the biological roles of individual genes from knowledge of their behavior in the increasing variety of different conditions that are coming under study using the tools of functional genomics.

描述（由申请人提供）：在过去十年中，全基因组研究的爆炸式增长已经清楚地表明，需要一种新的范式来整合生物信息并将其传播给研究界。因此，本提案的总体目标是设计和实施系统，使基因组数据集内所含信息的持续整合成为可能，至少包括基因表达、2-杂交、合成致死率和系统性缺失研究，并使研究界能够获得整合的信息，最初通过酵母基因组数据库（SGD），然后通过其他模式生物数据库，我们创建了一个普遍适用的系统，并将其提交给通用模式生物数据库（GMOD）项目。我们设想，从数据集的信息将成为通过2个一般路线访问：第一，数据集成系统将是一个指南，馆长在评估什么是已知的基因的功能，特别是那些基因是鲜为人知的;第二，我们将组织集成的数据，在一个持续的基础上，到一个可以直接查询的模式。通过提供多种信息来源和工具，以新的和更好的方式整合和查询它们，我们的目标是帮助生物学家在更全球化的背景下看到感兴趣的单个基因或途径。同样重要的是，我们希望利用功能基因组学的工具，通过了解基因在越来越多的不同条件下的行为，来增加我们对单个基因的生物学作用的认识。