IMPACT OF TUBERCULOSIS ON HIV DISEASE

描述：(改编自申请者摘要)这一假设 建议是结核病和艾滋病毒在活跃期间的相互作用 在结核和结核分枝杆菌感染的地方，使宿主容易患上 通过病毒学和免疫学事件和 巨噬细胞与T细胞的相互作用在这一过程中起着核心作用 进程。该提案的具体目的是：1.确定 巨噬细胞与T细胞在支持HIV扩增中的相互作用 结核病患者的负担和增强的艾滋病毒细胞致病性。2. HIV基因(V3环异质性)和表型(SI/NSI和 共受体使用)在HIV感染患者中的系统性和局部性 患有肺结核。3.抗HIV细胞(CD4和CD8)和 确诊时的体液(中和抗体)免疫反应 HIV感染患者的系统和局部结核病 肺结核。

DESCRIPTION: (Adapted from Applicant's Abstract) The hypothesis of this proposal is that the interaction of tuberculosis and HIV during active tuberculosis and at sites of M.tuberculosis infection, predisposes the host to progression of HIV disease through both virologic and immunologic events and that the interaction of macrophages with T cells plays a central,role in this process. The specific aims of the proposal are 1. Determination of the role of the interaction of macrophages with T-cells in supporting expansion of HIV burden and enhanced HIV cytopathicity in patients with tuberculosis. 2. Determination of HIV genotype (V3 loop heterogeneity) and phenotype (SI/NSI and co-receptor usage) both systematically and locally in HIV-infected patients with tuberculosis. 3. Determination of anti-HIV cellular (CD4 and CD8) and humoral (neutralizing antibody) immune reponses at the time of diagnosis of tuberculosis both systemically and locally in HIV infected patients with tuberculosis.