Biosafety

生物安全

• 批准号: 7933420
• 负责人: Zahra Toossi Toossi
• 金额: $ 11.72万
• 依托单位: CASE WESTERN RESERVE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-08-17 至 2010-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7933420
• 关键词: Acquired Immunodeficiency Syndrome; Arts; Biomedical Research; Blood; Cells; Communicable Diseases; Communities; Development; Floor; HIV; Human; Human Resources; Indium; Institution; Investigation; Laboratories; Lung; Methodology; Mission; Molecular; Mononuclear; Mycobacterium tuberculosis; Procedures; Regulation; Research; Research Personnel; Resources; Safety; Sampling; Services; Techniques; Time; Training; Transcriptional Activation; Tuberculosis; Virulent; Workplace; base; good laboratory practice; meetings; member; pathogen; success; translational study

The mission of the Biosafety Core is two-fold. First and foremost, the core provides a fully managed, equipped, and safe working environment for the study of HIV, Mycobactetium tubercu/osis (MTB) and other infectious pathogens. Secondly, the core actively develops state-of-the-art molecular methodologies for assessment of host/pathogen interactions for translational applications, such as the development of real-time quantitative PCR methodologies for the study of HIV replication and diversity in research samples. In addition, the core personnel have assumed the responsibility for training all users in good laboratory practices, periodic retraining to assure compliance with laboratory regulations, and providing services to promote research by all investigators in the CWRU/UHC research community. Dedicated BL-3 and BL-2+ laboratories are located across from each other on the 10th floor of the Biomedical Research Building in the Division of Infectious Diseases. A five-member Biosafety Committee meets to supervise safety procedures, and a six-member Scientific Team meets to determine developmental direction by the core on a quartedy basis. The activities of this core are essential to the success of CFAR, as both safety in investigation of biohazardous pathogens and development of new methodologies to assess host/HIV interactions constitute key elements in the AIDS research efforts at CWRU/UHC. The unique aspects of the core (i.e., the ability to study the interaction between HIV and virulent Mycobacterium tuberculosis), underscores the importance of this core as a major research strength of the CWRU/UHC CFAR.

生物安全核心的使命有两个。首先也是最重要的，核心提供了一个完全管理的、装备齐全的、 为研究 HIV、结核分枝杆菌/病 (MTB) 和其他传染性病原体提供安全的工作环境。 其次，核心积极开发最先进的分子方法来评估宿主/病原体 转化应用的相互作用，例如实时定量 PCR 方法的开发 研究样本中艾滋病毒复制和多样性的研究。此外，核心人员承担了 负责对所有用户进行良好实验室规范的培训，定期进行再培训以确保遵守实验室规范 法规，并提供服务以促进 CWRU/UHC 研究界所有研究人员的研究。 专用的 BL-3 和 BL-2+ 实验室位于生物医学中心 10 楼对面 传染病科研究大楼。五人生物安全委员会开会监督 安全程序，以及一个由六名成员组成的科学团队开会，确定核心的发展方向 四基础。 该核心的活动对于 CFAR 的成功至关重要，因为生物危害调查的安全性 病原体和评估宿主/艾滋病毒相互作用的新方法的开发构成了艾滋病的关键要素 CWRU/UHC 的研究工作。核心的独特方面（即研究艾滋病毒之间相互作用的能力） 和强毒力结核分枝杆菌），强调了这一核心作为该中心主要研究力量的重要性 CWRU/UHC CFAR。