Biosafety

生物安全核心的使命有两个方面。首先，核心提供了一个完全管理，装备， 为HIV、结核分枝杆菌（MTB）和其他传染性病原体的研究提供安全的工作环境。 其次，核心积极发展最先进的分子方法学，用于评估宿主/病原体 翻译应用的相互作用，如实时定量PCR方法的发展， 研究样本中的艾滋病毒复制和多样性。此外，核心人员还承担了 负责对所有用户进行良好实验室规范培训，定期进行再培训，以确保符合实验室规范 法规，并提供服务，以促进所有研究人员在CWRU/UHC研究界的研究。 专用BL-3和BL-2+实验室位于生物医学中心10楼对面 传染病科研究大楼。一个五人生物安全委员会开会监督 安全程序，一个六人科学小组开会，以确定发展方向的核心， 四分之一基 这一核心的活动对于CFAR的成功至关重要，因为在调查生物危害性物质时， 病原体和开发新的方法来评估宿主/HIV相互作用是艾滋病研究的关键因素 在CWRU/UHC的研究工作。核心的独特方面（即，研究艾滋病病毒和人类免疫缺陷病毒 和致命的结核分枝杆菌），强调了这一核心的重要性，作为一个主要的研究力量， CWRU/UHC CFAR。

The mission of the Biosafety Core is two-fold. First and foremost, the core provides a fully managed, equipped, and safe working environment for the study of HIV, Mycobactetium tubercu/osis (MTB) and other infectious pathogens. Secondly, the core actively develops state-of-the-art molecular methodologies for assessment of host/pathogen interactions for translational applications, such as the development of real-time quantitative PCR methodologies for the study of HIV replication and diversity in research samples. In addition, the core personnel have assumed the responsibility for training all users in good laboratory practices, periodic retraining to assure compliance with laboratory regulations, and providing services to promote research by all investigators in the CWRU/UHC research community. Dedicated BL-3 and BL-2+ laboratories are located across from each other on the 10th floor of the Biomedical Research Building in the Division of Infectious Diseases. A five-member Biosafety Committee meets to supervise safety procedures, and a six-member Scientific Team meets to determine developmental direction by the core on a quartedy basis. The activities of this core are essential to the success of CFAR, as both safety in investigation of biohazardous pathogens and development of new methodologies to assess host/HIV interactions constitute key elements in the AIDS research efforts at CWRU/UHC. The unique aspects of the core (i.e., the ability to study the interaction between HIV and virulent Mycobacterium tuberculosis), underscores the importance of this core as a major research strength of the CWRU/UHC CFAR.