CORE--Biosafety Core

生物安全中心的使命是双重的。首先，该中心为研究艾滋病毒、结核分枝杆菌（MTB）和其他传染性病原体提供了一个管理充分、装备齐全和安全的工作环境。其次，核心人员积极开发用于翻译应用的宿主/病原体相互作用评估的最先进分子方法，例如开发用于研究HIV复制和研究样本多样性的实时定量PCR方法。此外，核心人员还承担了对所有用户进行良好实验室规范培训的责任，定期进行再培训以确保遵守实验室法规，并为促进CWRU/UHC研究界所有研究者的研究提供服务。专门的BL-3和BL-2+实验室位于生物医学中心的10楼，彼此相对

The mission of the Biosafety Core is two-fold. First and foremost, the core provides a fully managed, equipped, and safe working environment for the study of HIV, Mycobacterium tuberculosis (MTB) and other infectious pathogens. Secondly, the core actively develops state-of-the-art molecular methodologies for assessment of host/pathogen interactions for translational applications, such as the development of real-time quantitative PCR methodologies for the study of HIV replication and diversity in research samples. In addition, the core personnel have assumed the responsibility for training all users in good laboratory practices, periodic retraining to assure compliance with laboratory regulations, and providing services to promote research by all investigators in the CWRU/UHC research community. Dedicated BL-3 and BL-2+ laboratories are located across from each other on the 10th floor of the Biomedical Research Building in the Division of Infectious Diseases. A five-member Biosafety Committee meets to supervise safety procedures, and a six-member Scientific Team meets to determine developmental direction by the core on a quarterly basis. The activities of this core are essential to the success of CFAR, as both safety in investigation of biohazardous pathogens and development of new methodologies to assess host/HIV interactions constitute key elements in the AIDS research efforts at CWRU/UHC. The unique aspects of the core (i.e., the ability to study the interaction between HIV and virulent Mycobacterium tuberculosis), underscores the importance of this core as a major research strength of the CWRU/UHC CFAR.