MICROFABRICATION FOR BIOMEDICAL RESEARCH

用于生物医学研究的微细加工

• 批准号: 6413433
• 负责人: SETH GOLDSTEIN
• 金额: --
• 依托单位: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6413433
• 关键词: biomedical equipment development; capillary electrophoresis; cell sorting; miniature biomedical equipment

New materials and techniques have made it possible to perform microfabrication with a modest investment in money and space. This has opened up the possibility of the Division of Bioengineering and Physical Sciences supplying intramural investigators with custom made micro components to perform capillary electrophoresis, capture and detection of antibodies, selection and sorting of cells, patterning of proteins and many other functions. Integration of many of these functions is the ultimate goal. When developed, these components will enable processing to be done with smaller sample sizes, smaller reagent volumes, higher speeds, more accuracy, and less human intervention. The initial phases of this initiative have involved literature studies, determination of potential users here at NIH, and determining the equipment and other resources needed to manufacture the new devices. In addition, collaborations with other institutions in the area are being aggressively pursued to minimize the startup time. Designs for very simple devices are in progress, and concepts for more advanced devices are being explored.

新的材料和技术使得人们能够以适度的资金和空间投资进行微制造。这为生物工程和物理科学部提供内部研究人员定制的微型组件以执行毛细管电泳，抗体捕获和检测，细胞选择和分选，蛋白质图案化和许多其他功能开辟了可能性。一体化 其中许多功能是最终目标。当开发完成后，这些组件将使处理能够以更小的样本量、更小的试剂体积、更高的速度、更高的准确性和更少的人为干预来完成。该计划的初始阶段包括文献研究，确定NIH的潜在用户，以及确定制造新设备所需的设备和其他资源。此外，与 该地区的其他机构正在积极争取尽量缩短启动时间。非常简单的设备的设计正在进行中，更先进的设备的概念正在探索中。