ADVANCED DENTAL RESTORATIVE SYSTEMS

高级牙科修复系统(ADRS)计划项目 是来自加州大学的研究人员共同努力的成果 德克萨斯健康科学中心(UTHSCSA)和研究所 (SWRI)。这个跨学科的研究团队 生物学家、化学家和材料科学家将开发一种非 收缩耐磨牙本质刺激牙齿修复更换 银汞合金。该项目由三个核心组成， 旨在将三个研究项目整合为一个协调一致的目标- 定向，努力。管理核心管理资源， 监控所有计划活动，监督研究活动，以及 为个别项目提供技术转让。这个 研发核心包括三个研究项目，以 开发：(I)旨在提高耐磨性和 树脂复合材料的耐久性(II)一种液晶树脂单体 以减少聚合收缩，以及(Iii)第三牙本质 重组骨形态发生的刺激系统 蛋白质。树脂开发项目包括氧化钽 和二氧化硅纳米颗粒填充到传统的双GMA和 液晶基质树脂大幅提升整体性能 树脂基修复材料的性能。空洞 治疗将形态发生蛋白放入准备好的牙齿中以 刺激牙本质形成，并提供生物创造的内部 密封以防止再次感染。生物材料测试核心测试 用于生物相容性和诱变性的材料配方和 测量树脂复合材料的物理和机械性能 配方。虽然个别项目有潜力生产 重大进展，综合研究项目将产生 由生物活性牙本质模拟洞组成的修复系统 衬里具有耐磨性，纳米填充，无收缩树脂复合材料 它是牙科汞齐的一种可行的替代品。

The Advanced Dental Restorative Systems (ADRS) program project is a collaborative effort between investigators from the University of Texas Health Science Center(UTHSCSA)and Research Institute (SwRI). This interdisciplinary research team of biologists,chemists,and materials scientists will develop a non- shrinking wear resistant dentin stimulating dental restorative replace silver amalgam. The program project is composed of three cores, designed to integrate three research projects into a coordinated, goal- oriented, effort. The Administrative Core manages resources, monitors all program activities, oversees research activities, and provides technology transfer for the individual projects. The Research and Development Core includes three research projects to develop: (I) nanofillers designed to improve the wear resistance and durability of the resin composites (ii) a liquid crystal resin monomer to reduce polymerization shrinkage, and (iii) a tertiary dentin stimulation system of recombinant forms of bone morphogenetic proteins. The resin development projects incorporate tantalum oxide and silica nanoparticles fillers into both conventional bis-GMA and liquid-crystal matrix resins to substantially improve the overall performance of resin-based restorative materials. The cavity treatment places morphogenetic proteins into the prepared tooth to stimulate dentin formation and provide a biologically created internal seal against re-infection. The Biomaterials Testing Core tests material formulations for biocompatability and mutagenicity and measures physical and mechanical properties of the resin composite formulations. While individual projects have the potential to produce significant advances, the integrated research projects will produce a restorative system composed of a bio-active dentin simulating cavity liner with a wear resistance, nanofilled, no shrinkage resin composite which is a viable alternate to dental amalgam.