New Non-invasive Imaging Methods For Biomedical Applicat

生物医学应用的新型非侵入性成像方法

• 批准号: 6541712
• 负责人: HAN WEN
• 金额: --
• 依托单位: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6541712
• 关键词: bioimaging /biomedical imaging; biomedical equipment development; clinical biomedical equipment; clinical research; heart contraction; heart imaging /visualization /scanning; heart motion; human subject; magnetic resonance imaging; noninvasive diagnosis; patient oriented research; technology /technique development

In the last year we focused our effot and made progress in the area of quantitative contractile function assessment of the human heart in vivo. Based on the stimulated-echo phase contrast method DENSE, which was proposed for micro-imaging and applied successfully in the human heart by our group,we optimized the technique for single breath-hold in vivo application in patients. Using a state-of-the-art 1.5 tesla whole-body clinical scanner, the technology is now able to quantify the motion of the entire left ventricular wall in three-dimensional space in a breath-hold of 15 heartbeats. For other cardiac MRI exams that need more than a breath-hold, we developed a motion-navigator technique that tracks the actual position of the heart from beat to beat, with improved reliability for individual patients than diaphragm based methods. With this method, many exams can be reliably performed under normal breathing condition. We also demonstrated a novel vectorized motion imaging method that may have interesting applications in small animal MRI.

在过去的一年里，我们集中精力，在人体心脏收缩功能定量评估领域取得了进展。基于本小组提出并成功应用于人体心脏微成像的刺激回波相位对比法DENSE，我们优化了该技术在患者体内单次屏气的应用。使用最先进的1.5特斯拉全身临床扫描仪，该技术现在能够在屏住呼吸15次心跳的情况下，在三维空间中量化整个左心室壁的运动。对于其他不需要屏气的心脏MRI检查，我们开发了一种运动导航技术，可以跟踪心脏从一次跳动到另一次跳动的实际位置，与基于隔膜的方法相比，它对个体患者的可靠性更高。使用这种方法，可以在正常呼吸条件下可靠地进行许多检查。我们还展示了一种新的矢量运动成像方法，可能在小动物MRI中有有趣的应用。