New Non-invasive Imaging Methods For Biomedical Applicat

在过去的一年里，我们集中精力在活体心脏收缩功能的定量评估领域取得了进展。在本课题组提出并成功应用于人体心脏显微成像的刺激回波相位衬比法Dense的基础上，我们优化了单次屏气在患者体内的应用技术。使用最先进的1.5特斯拉全身临床扫描仪，这项技术现在能够在15次心跳的屏息下量化整个左室壁在三维空间的运动。对于其他需要屏气以外的心脏MRI检查，我们开发了一种运动导航仪技术，可以跟踪心脏从一次跳动到另一次跳动的实际位置，与基于横隔膜的方法相比，对单个患者来说可靠性更高。有了这种方法，许多检查都可以在正常呼吸条件下可靠地进行。我们还展示了一种新的矢量化运动成像方法，该方法可能在小动物MRI中有有趣的应用。

In the last year we focused our effot and made progress in the area of quantitative contractile function assessment of the human heart in vivo. Based on the stimulated-echo phase contrast method DENSE, which was proposed for micro-imaging and applied successfully in the human heart by our group,we optimized the technique for single breath-hold in vivo application in patients. Using a state-of-the-art 1.5 tesla whole-body clinical scanner, the technology is now able to quantify the motion of the entire left ventricular wall in three-dimensional space in a breath-hold of 15 heartbeats. For other cardiac MRI exams that need more than a breath-hold, we developed a motion-navigator technique that tracks the actual position of the heart from beat to beat, with improved reliability for individual patients than diaphragm based methods. With this method, many exams can be reliably performed under normal breathing condition. We also demonstrated a novel vectorized motion imaging method that may have interesting applications in small animal MRI.