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Mouse coronary micro computed tomography

Mouse coronary micro computed tomography
小鼠冠状动脉显微计算机断层扫描
批准号：
8558076
负责人：
HAN WEN
金额：
$8.53万
依托单位：
NATIONAL HEART, LUNG, AND BLOOD INSTITUTE
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/8558076
关键词：
AnatomyApoE knockout mouseCoronaryCoronary ArteriosclerosisCoronary arteryDataDevelopmentGoalsHeartImageJournalsLesionMusOperative Surgical ProceduresPhasePreparationProtocols documentationPublicationsReportingSpecimenStructureSynchrotronsVariantWorkX-Ray Computed Tomographybasemouse model

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英文摘要
Prior to our study, microCT of coronary artery casts have shown anatomical variations in genetically modified mouse models, but has not been developed to image the coronary wall structures in mouse models of coronary artery disease. We have developed the imaging protocol and obtained data in apoE knockout mice that demonstrate coronary wall and plaque imaging in intact hearts. We have successfully imaged the coronary artery wall of mouse heart specimens with both tabletop and synchrotron based microCTs. The results are reported in a publication in Journal of Anatomy. Further work will focus on the appropriate mouse model and surgical preparation protocol for coronary artery lesions.
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