New imaging techniques

新的成像技术

• 批准号: 7734998
• 负责人: HAN WEN
• 金额: $ 158.72万
• 依托单位: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/7734998
• 关键词: Area; Atherosclerosis; Cardiac; Cardiovascular system; Carotid Arteries; Clinical; Collaborations; Data; Diagnostic; Family suidae; Goals; Human; Image; Imaging Techniques; Ischemia; Magnetic Resonance Imaging; Microscopic; Modeling; Patients; Pattern; Perfusion; Purpose; Structure; Sus scrofa; Techniques; Testing; Time; Work; base; biological research; cardiography; improved; interest; validation studies

As a continuation of the work in MR imaging of cardiac function, we performed patient tests comparing displacement-encoded MRI assessment (DENSE) with echo-cardiography assessment in collaboration with two clinical groups, and showed that the new MRI assessment significantly improves the sensitivity in detecting abnormal function. In a related project we began to combine cardiac perfusion and function imaging and obtained first results in a pig ischemia model. Using a similar technique, we finished the first validation study in humans on the carotid artery regional compliance pattern. This serves as the basis to look at the relationship between regional compliance distribution and atherosclerosis. In the area of x-ray imaging, we constructed a benchtop scanner of a new technique that relates the image contrast to microscopic structures, and obtained first data demonstrating the principle.

作为心脏功能磁共振成像工作的延续，我们与两个临床小组合作进行了患者测试，比较了位移编码MRI评估（DENSE）与超声心动图评估，结果表明新的MRI评估显著提高了检测异常功能的灵敏度。 在一个相关的项目中，我们开始将联合收割机心脏灌注和功能成像结合起来，并在猪缺血模型中获得了第一个结果。 使用类似的技术，我们完成了对人类颈动脉区域顺应性模式的首次验证研究。这是研究区域顺应性分布与动脉粥样硬化关系的基础。 在X射线成像领域，我们构建了一种新技术的台式扫描仪，该技术将图像对比度与显微结构联系起来，并获得了演示原理的第一批数据。

项目成果

The potential for Hall effect breast imaging.

霍尔效应乳腺成像的潜力。

• DOI: 10.3233/bd-1998-103-418
• 发表时间: 1998
• 期刊: Breast disease
• 作者: Wen,H;Balaban,RS
• 通讯作者: Balaban,RS

Effect of muscle action and metabolic strain on oxidative metabolic responses in human skeletal muscle.

肌肉活动和代谢应变对人体骨骼肌氧化代谢反应的影响。

• DOI: 10.1152/jappl.1999.87.5.1768
• 发表时间: 1999
• 期刊: Journal of applied physiology (Bethesda, Md. : 1985)
• 作者: Combs,CA;Aletras,AH;Balaban,RS
• 通讯作者: Balaban,RS

Circumferential strain in the wall of the common carotid artery: comparing displacement-encoded and cine MRI in volunteers.

• DOI: 10.1002/mrm.21621
• 发表时间: 2008-07
• 期刊: MAGNETIC RESONANCE IN MEDICINE
• 影响因子: 3.3
• 作者: Lin, Alexander P.;Bennett, Eric;Wisk, Lauren E.;Gharib, Morteza;Fraser, Scott E.;Wen, Han
• 通讯作者: Wen, Han

Shielding of piezoelectric ultrasonic probes in Hall effect imaging.

霍尔效应成像中压电超声探头的屏蔽。

• DOI: 10.1177/016173469802000305
• 发表时间: 1998
• 期刊: Ultrasonic imaging
• 影响因子: 2.3
• 作者: Wen,H;Bennett,E;Wiesler,DG
• 通讯作者: Wiesler,DG

Detection of myocardial capillary orientation with intravascular iron-oxide nanoparticles in spin-echo MRI.

在旋转回声 MRI 中用血管内氧化铁纳米颗粒检测心肌毛细血管方向。

• DOI: 10.1002/mrm.20827
• 发表时间: 2006
• 期刊: Magnetic resonance in medicine
• 影响因子: 3.3
• 作者: Vignaud,Alexandre;Rodriguez,Ignacio;Ennis,DanielB;DeSilva,Ranil;Kellman,Peter;Taylor,Joni;Bennett,Eric;Wen,Han
• 通讯作者: Wen,Han