Advanced x-ray imaging and computed tomography

先进的 X 射线成像和计算机断层扫描

• 批准号: 8557937
• 负责人: HAN WEN
• 金额: $ 85.29万
• 依托单位: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8557937
• 关键词: Abdomen; Biological; Development; Diffusion Magnetic Resonance Imaging; Dose; Goals; Image; Methods; Microscopic; Microscopy; Molecular Probes; Motion; Pathology; Phase; Physiological; Radiation; Sampling; Speed; Structure; Techniques; Technology; X-Ray Computed Tomography; bioimaging; clinical application; coping; density; interest; research study

On the quest for high sensitivity x-ray phase-contrast imaging, we fabricated the first 200 nm period hard x-ray gratings and performed the first phase-contrast imaging experiments with such high density gratings in the world. We also proposed a new way of doing x-ray microscopy which is particularly suitable for biological samples and identified molecular probes for this technology. We invented a method to speed up x-ray phase-contrast imaging which is a significant challenge for clinical applications of this technology.

为了寻求高灵敏度的X射线位相衬度成像，我们制作了世界上第一个200 nm周期的硬X射线光栅，并利用这种高密度光栅进行了第一次位相衬度成像实验。我们还提出了一种特别适合于生物样品的X射线显微技术，并为这项技术确定了分子探针。我们发明了一种加速X射线相衬成像的方法，这对这项技术的临床应用是一个巨大的挑战。