TRAINING IN NEUROBEHAVIOR/NEUROIMMUNE ADDICTION RESEARCH

产品说明：（由申请人提供）这是一份重新提交的多学科药物滥用研究培训计划申请，题为神经行为/神经免疫成瘾研究培训，这是一个由药物滥用和神经行为药理学培训（T32 DA 07097 -20）和精神神经免疫学和物质滥用培训（T32 DA 07239 -10）赠款组成的联合计划。结合这些程序是一个重要的相互作用的逻辑延伸，表现为联合研究务虚会，两个或多个实验室之间的现有和计划的合作，重叠的研究兴趣，NIDA/NIH的研究支持和联合奖学金和导师。它的目标是培养研究人员谁将能够研究成瘾性疾病的问题，无论是在分析的基本水平或更全球的水平（如细胞生物学或多系统/行为）作为他们的主要重点，但能够讨论，整合和合作与其他工作在其他层次的分析。例如，关于成瘾性药物影响培养物中的免疫系统细胞的知识或甚至成瘾性药物如何影响培养物中的免疫系统细胞的知识，而不考虑其对以整合方式发挥功能的系统（例如CNS和内分泌系统）的影响，可能与体内情况几乎没有关联。再加上第二（如适应）或第三后果（如戒断应激）以及原因、后果和预防或治疗干预策略的复杂性，要求接受过成瘾性疾病下一代研究人员培训的人接受广泛和狭义的教育。培训将强调掌握一两种知识基础和研究方法，同时接触教员和学员并与他们合作，对某一全球性问题，如某一特定类别药物的滥用和成瘾问题，采取相互重叠和更多样化的办法。为了实现这一目标，教育结构包括一个正式的，量身定制的课程，在神经免疫相互作用的具体课程，和神经精神药理学，一个积极的研讨会和会议时间表和跨相关学科的教师研究联系。初级培训教师包括具有医学博士学位的科学家。和/或博士拥有药理学、心理学、免疫学和神经科学学位的学生，他们是资金充足、受人尊敬的研究人员，熟悉各种研究方法。该培训计划将培养具有研究职业知识和经验的科学家，这些科学家类似于已经在更高级的教师下完成培训并在学术和政府机构或行业中担任职务的学员。该请求是为11个博士前职位和10个博士后职位在合并后的程序，从以前的要求减少总数。我们设想，合并后的计划将加强和扩大各自已经享有的少量成功。

DESCRIPTION: (provided by applicant) This is a resubmission of an application for a multiple disciplinary drug abuse research training program, entitled Training in Neurobehavior/Neuroimmune Addiction Research, which is a combined program consisting of the Training in Drug Abuse and Neurobehavioral Pharmacology T32 DA07097-20) and Training in Psychoneuroimmunology and Substance Abuse T32 DA07239-10) grants. Combining these programs is a logical extension of significant interactions manifest as combined research retreats, existing and planned collaborations between two or more laboratories, overlapping research interests, NIDA/NIH research support and joint advisorships and mentorships. Its goal is to train researchers who will be able to study problems of addictive diseases at either fundamental levels of analyses or more global levels (e.g. cellular biology or multiple systems/behavioral) as their primary focus but to be able to discuss, integrate and collaborate with others working at other levels of analyses. For example, knowledge that, or even how an addictive drug affects immune system cells in culture, without regard to its influence upon systems which function in an integrative fashion (e.g. CNS and endocrine system) may have little relevance to the in vivo situation. Add to this the secondary (e.g. adaption) or tertiary consequences (e.g. withdrawal stress) and the complexity of the causes, consequences and prevention or treatment intervention strategies requires that people trained as the next generation of researchers in addictive diseases be schooled broadly, as well as narrowly. Training will emphasize mastery of one or two knowledge bases and research methodologies, coupled with exposure to and collaboration with faculty and trainees with overlapping and more diverse approaches to a global problem, such as abuse of and addiction to a particular class of drugs. To accomplish this, educational structure includes a formal, tailored curriculum, specific courses in Neuro-Immune Interactions, and Neuropsychopharmacology, an active seminar and conference schedule and research linkages with faculty across the relevant disciplines. The primary training faculty includes scientists with M.D. and/or Ph.D. degrees in pharmacology, psychology, immunology and neuroscience who are well-funded and respected researchers and who are conversant with a wide array of research methodologies. This training program will develop scientists who have the knowledge and experience for research careers similar to trainees who have already completed training under the more senior faculty and hold positions in academic and government institutions or industry. The request is for 11 predoctoral positions and 10 postdoctoral positions in the combined program, a reduction in overall numbers from the previous request. We envision the combined program will strengthen and broaden the modicum of success each already enjoys in its own right.