TRAINING IN NEUROIMMUNE/NEUROBEHAVIOR ADDICTION RESEARCH

描述（由申请人提供）：这是一个重新提交的跨学科药物滥用研究培训计划的更新申请，题为神经免疫/神经行为成瘾研究培训（T32 DA 007097 -25）。该培训计划已经运作了5年，结合了明尼苏达大学两个NIDA资助项目的优势：药物滥用和神经行为药理学培训（T32 DA 07097 -20）和PNI和药物滥用培训（T32 DA 07239 -10）。联合培训计划满足了一个公认的需要，在跨学科领域培养博士前和博士后水平的生物医学科学家，该领域专注于滥用药物与神经和免疫系统的相互作用，并将我们对这些生理相互作用的理解与他们的行为相结合。培训方案的一个重要组成部分是考虑滥用药物作为艾滋病毒/艾滋病的辅助因素的作用，特别是与神经艾滋病有关的作用。以前的学员现在在学术界、政府和工业界担任有影响力的职位。我们的25名教师初级培训师是明尼苏达大学及其附属机构的神经科学家，心理学家，药理学家，免疫学家和微生物学家。在这些学科中，我们有实验室科学家和临床教师，使该计划能够吸引优秀的学员。资金充足的初级培训教师具有丰富的导师经验，并致力于在这个跨学科的环境中培养博士前学生和博士后研究员。我们还有具有选定专门知识的共同导师，他们将提供培训内容，并协助指导受训人员。为了完成我们的培训使命与我们现有的资源，我们要求10个博士后和5个博士后职位。一个成功的培训计划的所有要素都到位，并运作良好：正式的博士前课程，包括神经免疫相互作用和神经精神药理学课程;双月研讨会系列;最重要的是，在相关学科的教师之间建立联系，合议和创造性的关系。自上次提交以来，我们在积累的经验基础上增加了两个组成部分，以进一步加强我们学员的跨学科转化研究经验：1）关于“药物滥用到床边”的临床课程，重点是海洛因、可卡因/甲基苯丙胺、尼古丁和成瘾的医学并发症，包括艾滋病并发症，以及2）关于“艾滋病毒/艾滋病：发病机制，治疗和预防”由临床教师谁直接处理艾滋病患者领导。(Lay这是明尼苏达大学跨学科培训计划的竞争性更新，重点是滥用药物与神经和免疫系统的相互作用，并将我们对这些生理相互作用的理解与其行为对应物相结合，包括滥用药物作为艾滋病毒/艾滋病辅助因子的作用。为了完成我们的培养使命，需要10个博士前和5个博士后职位。

DESCRIPTION (provided by applicant): This is a resubmitted application for renewal of an interdisciplinary Drug Abuse Research Training Program, entitled Training in Neuroimmune/Neurobehavior Addiction Research (T32 DA007097-25). This training program has operated for the past 5 years and combines the strengths of two NIDA-funded programs at the University of Minnesota: Training in Drug Abuse and Neurobehavioral Pharmacology (T32 DA07097-20) and Training in PNI and Substance Abuse (T32 DA07239-10). The combined training program meets a well-recognized need to train biomedical scientists at the pre- and postdoctoral levels in an interdisciplinary field that focuses on the interactions of drugs of abuse with the nervous and immune systems, and integrates our understanding of these physiological interactions with their behavioral counterparts. A critical component of the training program considers the role of drugs of abuse as co-factors in HIV/AIDS, specifically relating to NeuroAIDS. Former trainees now hold influential positions in academia, government, and industry. Our 25 faculty primary trainers are a talented group of neuroscientists, psychologists, pharmacologists, immunologists, and microbiologists at the University of Minnesota and affiliated institutions. Across these disciplines we have both laboratory-based scientists and clinical faculty, allowing the program to attract outstanding trainees. The well-funded primary training faculty has extensive experience as mentors and is committed to training predoctoral students and postdoctoral fellows in this interdisciplinary setting. We also have co-mentors with selected expertise that will provide training components and assist in the mentorship of the trainees. To fulfill our training mission with our available resources, we request 10 predoctoral and 5 postdoctoral positions. All of the elements of a successful training program are in place and are functioning well: a formal predoctoral curriculum, including courses in neuro-immune interactions and neuropsychopharmacology; a bimonthly seminar series; and, most importantly, linkages established, collegial, and creative relationships among the faculty across the relevant disciplines. Since the last submission, we have built on our accumulated experience and added two components that will further strengthen our trainees' interdisciplinary translational research experiences: 1) a clinical course on "Substance Abuse to the Bedside" that focuses on heroin, cocaine/ methamphetamine, nicotine, and the medical complications of addictions, including complications from AIDS, and 2) a new colloquium on "HIV/AIDS: Pathogenesis, Treatment, and Prevention" led by clinical faculty who deal directly with AIDS patients. (Lay summary) This is a competitive renewal for an interdisciplinary training program at the University of Minnesota that focuses on the interactions of drugs of abuse with the nervous and immune systems, and integrates our understanding of these physiological interactions with their behavioral counterparts, including the role of drugs of abuse as co-factors in HIV/AIDS. To fulfill our training mission, 10 predoctoral and 5 postdoctoral positions are requested.