Training in Neuroimmune/Neurobehavior Addiction Research

描述（由申请人提供）：这是一项跨学科药物滥用研究培训计划的更新申请，该计划名为神经免疫/神经行为成瘾研究培训（T32 DA 007097 -30），称为药物神经免疫学。药物神经免疫学培训计划<www.facebook.com/pniprogram>已经运作了十年，是明尼苏达大学两个以前由NIDA资助的计划的组合，即“药物滥用和神经行为药理学培训”（T32 DA 07097 -20）和“PNI和药物滥用培训”（T32 DA 07239 -10）。“联合培训计划满足了公认的需要，在跨学科和翻译领域培训博士前和博士后水平的生物医学科学家，重点是滥用药物与神经和免疫系统的相互作用，并将我们对这些生理相互作用的理解与他们的行为对应物相结合。我们培训这些领域的基础科学家和临床医生，使他们能够有效地相互交谈。培训方案的一个重要组成部分是考虑滥用药物作为艾滋病毒/艾滋病的辅助因素的作用，特别是与神经艾滋病有关的作用。前学员（在过去10年中有25名博士前和22名博士后）在学术界，政府和工业界担任有影响力的职位。我们的32名初级教师培训师是明尼苏达大学的神经科学家，心理学家，药理学家，免疫学家和微生物学家。在这些学科中，我们有实验室科学家和临床教师，使该计划能够吸引优秀的学员。我们资金雄厚的教师培训师有丰富的经验，作为导师，并致力于培养博士前学生和博士后研究员在这个跨学科的设置。我们也有共同导师与选定的专业知识谁将提供专门的培训内容。为了用我们现有的资源完成我们的培训使命，我们要求资助10个博士前和5个博士后职位。一个成功的培训计划的所有要素都到位，并有效地运作：正式的博士前课程，包括神经免疫相互作用和神经精神药理学课程;双月研讨会系列;最重要的是，建立联系，学院，跨学科的教师之间的创造性关系。自上次提交以来，我们在积累的经验的基础上，实施了两个部分，进一步加强了我们学员的跨学科转化研究经验：1）关于“药物滥用到床边”的临床课程，重点是海洛因、可卡因/甲基苯丙胺、尼古丁和成瘾的医学并发症，包括艾滋病并发症，以及2）关于“艾滋病毒/艾滋病：发病机制，治疗和预防”由临床教师谁直接处理艾滋病患者领导。 公共卫生相关性：这是明尼苏达大学跨学科培训计划的竞争性更新，该计划侧重于滥用药物与神经和免疫系统的相互作用，并将我们对这些生理相互作用的理解与其行为对应物相结合，包括滥用药物作为辅助因素的作用。 in HIV艾滋病毒/AIDS艾滋病.为了完成我们的培养使命，需要10个博士前和5个博士后职位。

DESCRIPTION (provided by applicant): This is an application for renewal of an interdisciplinary Drug Abuse Research Training Program titled Training in Neuroimmune/Neurobehavior Addiction Research (T32 DA007097-30) known as Pharmaconeuroimmunology. The Pharmaconeuroimmunology Training Program <www.facebook.com/pniprogram> has operated for ten years and resulted from the combination of two previously NIDA-funded programs at the University of Minnesota, Training in Drug Abuse and Neurobehavioral Pharmacology (T32 DA07097-20)" and "Training in PNI and Substance Abuse (T32 DA07239-10)." The combined training program meets a well-recognized need to train biomedical scientists at the pre- and postdoctoral levels in an interdisciplinary and translational field that focuses on the interactions of drugs of abuse with the nervous and immune systems, and integrates our understanding of these physiological interactions with their behavioral counterparts. We train basic scientists and clinicians in these fields to talk to one another productively. A critical component of the training program considers the role of drugs of abuse as co-factors in HIV/AIDS, specifically relating to NeuroAIDS. Former trainees (25 predoctoral and 22 postdoctoral in the past 10 years) hold influential positions in academia, government, and industry. Our 32 primary faculty trainers are a talented group of neuroscientists, psychologists, pharmacologists, immunologists, and microbiologists at the University of Minnesota. Across these disciplines we have both laboratory-based scientists and clinical faculty, allowing the program to attract outstanding trainees. Our well-funded faculty trainers have extensive experience as mentors and are committed to training predoctoral students and postdoctoral fellows in this interdisciplinary setting. We also have co-mentors with selected expertise who will provide specialized training components. To fulfill our training mission with our available resources, we request funding for 10 predoctoral and 5 postdoctoral positions. All of the elements of a successful training program are in place and are functioning efficiently and effectively: a formal predoctoral curriculum, including courses in neuro-immune interactions and neuropsychopharmacology; a bimonthly seminar series; and most importantly, linkages established, collegial, and creative relationships among the faculty across the disciplines. Since the last submission, we have built on our accumulated experience and implemented two components that have further strengthened our trainees' interdisciplinary translational research experiences: 1) a clinical course on "Substance Abuse to the Bedside" that focuses on heroin, cocaine/methamphetamine, nicotine, and the medical complications of addictions, including complications from AIDS, and 2) a new colloquium on "HIV/AIDS: Pathogenesis, Treatment, and Prevention" led by clinical faculty who deal directly with AIDS patients. PUBLIC HEALTH RELEVANCE: This is a competitive renewal for an interdisciplinary training program at the University of Minnesota that focuses on the interactions of drugs of abuse with the nervous and immune systems, and integrates our understanding of these physiological interactions with their behavioral counterparts, including the role of drugs of abuse as co-factors in HIV/AIDS. To fulfill our training mission, 10 predoctoral and 5 postdoctoral positions are requested.