TRAINING IN NEUROIMMUNE/NEUROBEHAVIOR ADDICTION RESEARCH

描述（由申请人提供）：这是一份重新提交的跨学科药物滥用研究培训计划的续期申请，题为神经免疫/神经行为成瘾研究培训（T32 DA007097-25）。这个培训项目已经运行了5年，结合了明尼苏达大学nida资助的两个项目的优势：药物滥用和神经行为药理学培训（T32 DA07097-20）和PNI和药物滥用培训（T32 DA07239-10）。该联合培训计划满足了培养跨学科领域的生物医学科学家的公认需求，该领域专注于药物滥用与神经和免疫系统的相互作用，并整合了我们对这些生理相互作用与行为对应的理解。培训计划的一个重要组成部分考虑药物滥用作为艾滋病毒/艾滋病的辅助因素的作用，特别是与神经艾滋病有关。以前的学员现在在学术界、政府和工业界担任有影响力的职位。我们的25名教师主要培训师是明尼苏达大学及其附属机构的一群才华横溢的神经科学家、心理学家、药理学家、免疫学家和微生物学家。在这些学科中，我们有实验室科学家和临床教师，使该项目吸引优秀的学员。资金充足的初级培训教师拥有丰富的导师经验，并致力于在这个跨学科的环境中培养博士生和博士后。我们也有一些具有特定专业知识的共同导师，他们将提供培训内容并协助指导学员。为完成我校现有资源的培养任务，现诚聘10名博士前、5名博士后。一个成功的培训计划的所有要素都已到位，并且运作良好：正式的博士前课程，包括神经免疫相互作用和神经精神药理学课程；两个月一次的系列讨论会；最重要的是，在相关学科的教师之间建立了联系，建立了学院和创造性的关系。自上次提交以来，我们在积累经验的基础上增加了两个组成部分，以进一步加强学员的跨学科转化研究经验：1)关于“药物滥用到床边”的临床课程，重点关注海洛因、可卡因/甲基苯丙胺、尼古丁和成瘾的医学并发症，包括艾滋病并发症；2)关于“艾滋病毒/艾滋病：“发病机制、治疗和预防”，由直接治疗艾滋病患者的临床教师领导。（Lay summary）这是明尼苏达大学跨学科培训项目的竞争性更新，该项目侧重于药物滥用与神经和免疫系统的相互作用，并整合了我们对这些生理相互作用与行为对应的理解，包括药物滥用作为艾滋病毒/艾滋病的辅助因素的作用。为实现本学院的培养目标，现拟招聘博士预科10名，博士后5名。

DESCRIPTION (provided by applicant): This is a resubmitted application for renewal of an interdisciplinary Drug Abuse Research Training Program, entitled Training in Neuroimmune/Neurobehavior Addiction Research (T32 DA007097-25). This training program has operated for the past 5 years and combines the strengths of two NIDA-funded programs at the University of Minnesota: Training in Drug Abuse and Neurobehavioral Pharmacology (T32 DA07097-20) and Training in PNI and Substance Abuse (T32 DA07239-10). The combined training program meets a well-recognized need to train biomedical scientists at the pre- and postdoctoral levels in an interdisciplinary field that focuses on the interactions of drugs of abuse with the nervous and immune systems, and integrates our understanding of these physiological interactions with their behavioral counterparts. A critical component of the training program considers the role of drugs of abuse as co-factors in HIV/AIDS, specifically relating to NeuroAIDS. Former trainees now hold influential positions in academia, government, and industry. Our 25 faculty primary trainers are a talented group of neuroscientists, psychologists, pharmacologists, immunologists, and microbiologists at the University of Minnesota and affiliated institutions. Across these disciplines we have both laboratory-based scientists and clinical faculty, allowing the program to attract outstanding trainees. The well-funded primary training faculty has extensive experience as mentors and is committed to training predoctoral students and postdoctoral fellows in this interdisciplinary setting. We also have co-mentors with selected expertise that will provide training components and assist in the mentorship of the trainees. To fulfill our training mission with our available resources, we request 10 predoctoral and 5 postdoctoral positions. All of the elements of a successful training program are in place and are functioning well: a formal predoctoral curriculum, including courses in neuro-immune interactions and neuropsychopharmacology; a bimonthly seminar series; and, most importantly, linkages established, collegial, and creative relationships among the faculty across the relevant disciplines. Since the last submission, we have built on our accumulated experience and added two components that will further strengthen our trainees' interdisciplinary translational research experiences: 1) a clinical course on "Substance Abuse to the Bedside" that focuses on heroin, cocaine/ methamphetamine, nicotine, and the medical complications of addictions, including complications from AIDS, and 2) a new colloquium on "HIV/AIDS: Pathogenesis, Treatment, and Prevention" led by clinical faculty who deal directly with AIDS patients. (Lay summary) This is a competitive renewal for an interdisciplinary training program at the University of Minnesota that focuses on the interactions of drugs of abuse with the nervous and immune systems, and integrates our understanding of these physiological interactions with their behavioral counterparts, including the role of drugs of abuse as co-factors in HIV/AIDS. To fulfill our training mission, 10 predoctoral and 5 postdoctoral positions are requested.