TRAINING IN NEUROBEHAVIOR/NEUROIMMUNE ADDICTION RESEARCH

描述：（由申请人提供）这是一份多学科药物滥用研究培训计划的重新提交申请，名为神经行为/神经免疫成瘾研究培训，这是一个由药物滥用和神经行为药理学培训（T32 DA07097-20）和精神神经免疫学和药物滥用培训（T32 DA07239-10）资助组成的组合项目。结合这些项目是重要互动的逻辑延伸，表现为联合研究静修，两个或更多实验室之间现有和计划的合作，重叠的研究兴趣，NIDA/NIH研究支持以及联合顾问和指导。它的目标是培养研究人员谁将能够研究成瘾性疾病的问题，无论是在分析的基础水平或更多的全球水平（如细胞生物学或多系统/行为）作为他们的主要焦点，但能够讨论，整合和协作与他人在其他层面的分析工作。例如，关于成瘾药物如何影响培养免疫系统细胞的知识，而不考虑其对以综合方式运作的系统（例如中枢神经系统和内分泌系统）的影响，可能与体内情况几乎没有关系。再加上二级后果（如适应）或三级后果（如戒断压力），原因、后果和预防或治疗干预战略的复杂性要求对作为成瘾性疾病下一代研究人员受过培训的人进行广泛和狭隘的教育。培训将强调掌握一种或两种知识基础和研究方法，同时与教师和学员接触和合作，对一个全球性问题，例如对某一类药物的滥用和成瘾，采取重叠和更多样化的方法。为了实现这一目标，教育结构包括正式的，量身定制的课程，神经免疫相互作用的特定课程，神经精神药理学，积极的研讨会和会议时间表以及与相关学科的教师的研究联系。主要培训教师包括药理学、心理学、免疫学和神经科学领域的医学博士和/或博士学位的科学家，他们是资金充足、受人尊敬的研究人员，熟悉广泛的研究方法。该培训计划将培养具有研究职业知识和经验的科学家，类似于已经在更高级的教师下完成培训并在学术和政府机构或行业中担任职务的受训者。该请求是在合并计划中提供11个博士前职位和10个博士后职位，与之前的请求相比，总数减少了。我们设想，合并后的方案将加强和扩大各自已经取得的一点点成功。

DESCRIPTION: (provided by applicant) This is a resubmission of an application for a multiple disciplinary drug abuse research training program, entitled Training in Neurobehavior/Neuroimmune Addiction Research, which is a combined program consisting of the Training in Drug Abuse and Neurobehavioral Pharmacology T32 DA07097-20) and Training in Psychoneuroimmunology and Substance Abuse T32 DA07239-10) grants. Combining these programs is a logical extension of significant interactions manifest as combined research retreats, existing and planned collaborations between two or more laboratories, overlapping research interests, NIDA/NIH research support and joint advisorships and mentorships. Its goal is to train researchers who will be able to study problems of addictive diseases at either fundamental levels of analyses or more global levels (e.g. cellular biology or multiple systems/behavioral) as their primary focus but to be able to discuss, integrate and collaborate with others working at other levels of analyses. For example, knowledge that, or even how an addictive drug affects immune system cells in culture, without regard to its influence upon systems which function in an integrative fashion (e.g. CNS and endocrine system) may have little relevance to the in vivo situation. Add to this the secondary (e.g. adaption) or tertiary consequences (e.g. withdrawal stress) and the complexity of the causes, consequences and prevention or treatment intervention strategies requires that people trained as the next generation of researchers in addictive diseases be schooled broadly, as well as narrowly. Training will emphasize mastery of one or two knowledge bases and research methodologies, coupled with exposure to and collaboration with faculty and trainees with overlapping and more diverse approaches to a global problem, such as abuse of and addiction to a particular class of drugs. To accomplish this, educational structure includes a formal, tailored curriculum, specific courses in Neuro-Immune Interactions, and Neuropsychopharmacology, an active seminar and conference schedule and research linkages with faculty across the relevant disciplines. The primary training faculty includes scientists with M.D. and/or Ph.D. degrees in pharmacology, psychology, immunology and neuroscience who are well-funded and respected researchers and who are conversant with a wide array of research methodologies. This training program will develop scientists who have the knowledge and experience for research careers similar to trainees who have already completed training under the more senior faculty and hold positions in academic and government institutions or industry. The request is for 11 predoctoral positions and 10 postdoctoral positions in the combined program, a reduction in overall numbers from the previous request. We envision the combined program will strengthen and broaden the modicum of success each already enjoys in its own right.