Training in Neuroimmune/Neurobehavior Addiction Research

描述(由申请人提供)：这是一份名为《神经免疫/神经行为成瘾研究培训》(T32 DA007097-30)的跨学科药物滥用研究培训计划的续签申请，名为药物神经免疫学。药物神经免疫学培训计划&lt；www.facebook.com/pniProgram&gt；已经运作了十年，是明尼苏达大学两个以前由NIDA资助的药物滥用和神经行为药理学培训(T32 DA07097-20)和“PNI和药物滥用培训(T32 DA07239-10)”相结合的结果。联合培训计划满足了公认的需求，即在跨学科和翻译领域培训博士后和博士后生物医学科学家，重点研究滥用药物与神经和免疫系统的相互作用，并将我们对这些生理相互作用的理解与他们的行为同行结合起来。我们对这些领域的基础科学家和临床医生进行培训，使他们能够有效地相互交谈。培训计划的一个关键组成部分考虑滥用药物作为艾滋病毒/艾滋病的辅助因素的作用，特别是与神经艾滋病有关的因素。以前的学员(过去10年中有25名博士后和22名博士后)在学术界、政府和工业界担任有影响力的职位。我们的32名初级教师培训师是明尼苏达大学的一群才华横溢的神经学家、心理学家、药理学家、免疫学家和微生物学家。在这些学科中，我们既有以实验室为基础的科学家，也有临床教师，使该项目能够吸引优秀的学员。我们资金雄厚的师资培训师拥有丰富的导师经验，并致力于在这种跨学科的背景下培训博士后学生和博士后研究员。我们还拥有精选专业知识的共同导师，他们将提供专门的培训内容。为了用我们现有的资源完成我们的培训任务，我们申请资助10个博士后和5个博士后职位。一个成功的培训计划的所有要素都已到位，并正在高效地发挥作用：正式的博士前课程，包括神经免疫相互作用和神经精神药理学课程；双月系列研讨会；以及最重要的是，跨学科教职员工之间建立的、合作的和创造性的关系。自上一次提交以来，我们以积累的经验为基础，实施了两个组成部分，进一步加强了我们受训人员的跨学科转换研究经验：1)一个临床课程，重点是海洛因、可卡因/甲基苯丙胺、尼古丁和成瘾的医学并发症，包括艾滋病并发症；2)由直接与艾滋病患者打交道的临床教师领导的一个新的研讨会，主题为“艾滋病毒/艾滋病：发病机制、治疗和预防”。

DESCRIPTION (provided by applicant): This is an application for renewal of an interdisciplinary Drug Abuse Research Training Program titled Training in Neuroimmune/Neurobehavior Addiction Research (T32 DA007097-30) known as Pharmaconeuroimmunology. The Pharmaconeuroimmunology Training Program <www.facebook.com/pniprogram> has operated for ten years and resulted from the combination of two previously NIDA-funded programs at the University of Minnesota, Training in Drug Abuse and Neurobehavioral Pharmacology (T32 DA07097-20)" and "Training in PNI and Substance Abuse (T32 DA07239-10)." The combined training program meets a well-recognized need to train biomedical scientists at the pre- and postdoctoral levels in an interdisciplinary and translational field that focuses on the interactions of drugs of abuse with the nervous and immune systems, and integrates our understanding of these physiological interactions with their behavioral counterparts. We train basic scientists and clinicians in these fields to talk to one another productively. A critical component of the training program considers the role of drugs of abuse as co-factors in HIV/AIDS, specifically relating to NeuroAIDS. Former trainees (25 predoctoral and 22 postdoctoral in the past 10 years) hold influential positions in academia, government, and industry. Our 32 primary faculty trainers are a talented group of neuroscientists, psychologists, pharmacologists, immunologists, and microbiologists at the University of Minnesota. Across these disciplines we have both laboratory-based scientists and clinical faculty, allowing the program to attract outstanding trainees. Our well-funded faculty trainers have extensive experience as mentors and are committed to training predoctoral students and postdoctoral fellows in this interdisciplinary setting. We also have co-mentors with selected expertise who will provide specialized training components. To fulfill our training mission with our available resources, we request funding for 10 predoctoral and 5 postdoctoral positions. All of the elements of a successful training program are in place and are functioning efficiently and effectively: a formal predoctoral curriculum, including courses in neuro-immune interactions and neuropsychopharmacology; a bimonthly seminar series; and most importantly, linkages established, collegial, and creative relationships among the faculty across the disciplines. Since the last submission, we have built on our accumulated experience and implemented two components that have further strengthened our trainees' interdisciplinary translational research experiences: 1) a clinical course on "Substance Abuse to the Bedside" that focuses on heroin, cocaine/methamphetamine, nicotine, and the medical complications of addictions, including complications from AIDS, and 2) a new colloquium on "HIV/AIDS: Pathogenesis, Treatment, and Prevention" led by clinical faculty who deal directly with AIDS patients.