CORE--REPRODUCTIVE TOXICOLOGY

描述(申请人提供)：生殖和发育 毒理学研究核心负责五个子专业的活动 区域。这些活动包括新实验室的开发 基于人群的人类健康研究的分析方法。这项研究 这个核心的活动采取多学科的方法来解决问题 与人类生殖健康有直接关系。它们涉及一个或多个 更多的设施核心成员，通常至少有一个设施核心提供支持。 核心成员使用的实验设计包括临床研究，在 动物模型的体内研究和体外机制研究。 从历史上看，这个核心在流行病学和分子方面都很活跃 生殖毒理学方面。对于前一个方面，目标是 开发和应用基于人群的可靠生物标志物/分析方法 学习。对于后一方面，目标是通过以下方式了解机制 哪些外源物质会对男性和女性最脆弱的突起产生不利影响 和雌性生殖。

Description (provided by applicant): The Reproductive and Developmental Toxicology Research Core is responsible for activities in five sub-specialty areas. These activities range from the development of new laboratory analytical methods to population-based studies of human health. The research activities in this Core take a multi-disciplinary approach to solving problems that have direct relevance to human reproductive health. They involve one or more Facility Core members and usually at least one Facility Core for support. Experimental designs used by Core members include clinical investigations, in vivo studies with animal models, and in vitro mechanistic studies. Historically, this Core has been active in both epidemiological and molecular aspects of reproductive toxicology. For the former aspect, the goal is to develop and apply reliable biomarkers/analytical methods for population-based studies. For the latter aspect, the goal is to understand the mechanism, by which xenobiotics adversely affect the most vulnerable processes of both male and female reproduction.