MOUSE PATHOBIOLOGY: MODELS OF HUMAN DISEASE

小鼠病理学：人类疾病模型

• 批准号: 6452713
• 负责人: THOMAS J ROSOL
• 金额: $ 12.19万
• 依托单位: OHIO STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-06-01 至 2007-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6452713
• 关键词: MOUSE; PATHOBIOLOGY; MODELS; HUMAN; DISEASE

DESCRIPTION (Provided by applicant): The OSU Mouse Pathobiology training program is a four-year program designed to produce veterinary scientists capable of conducting independent and collaborative research using mouse models of human disease. Trainees will be selected from motivated and talented D.V.M. or D.V.M., Ph.D. candidates who are committed to careers in research. Trainees will complete one year of specialty education in veterinary pathology, clinical pathology, microbiology, or laboratory animal medicine that will include a three month rotation through the Laboratory Animal Program. The first year will be funded by the Department of Veterinary Biosciences. Then the T32 training program will require three years during which trainees will complete independent research projects within a training faculty's laboratory. Trainees without a Ph.D. degree will pursue a Ph.D. in Comparative and Experimental Pathobiology in the Department of Veterinary Biosciences. The research projects will focus on using mouse models to investigate the pathophysiology of significant human diseases. The training faculty (24 members) have focused research excellence in comparative cancer medicine, infectious diseases, immunology, and development of genetically altered mouse models of human disease. All training faculty use experimental mouse models of human disease in their work. The 24 training faculty represent a diverse spectrum of investigators in veterinary biosciences, internal medicine, medical biochemistry and physiology, cancer genetics, mouse genetics, surgery, molecular biology, and oral biology that have developed a network of collaborative interactions within The Ohio State University Health Sciences Center (consisting of seven colleges). The training faculty represent the Colleges of Veterinary Medicine, Medicine, Biologic Sciences, and Dentistry. The OSU Comprehensive Cancer Center (including its core services), James Cancer Hospital and Solove Research Institute, and transgenic cores of the Neurobiotechnology Center and Children's Hospital are organizations at the OSU that will facilitate the research programs and training faculty interaction. Selected formal courses will be chosen for trainees based on their needs and goals. Completion of the program will enable trainees to develop the skills necessary to design and conduct in vivo experiments and serve as resource persons in academic or industrial institutions to facilitate research projects using mouse models of human disease.

描述（由申请人提供）：OSU 小鼠病理学培训 该计划是一个为期四年的计划，旨在培养兽医科学家 能够使用鼠标进行独立和协作研究 人类疾病模型。学员将从积极进取、才华横溢的人中选拔 D.V.M.或 D.V.M.、博士致力于研究事业的候选人。 学员将完成一年的兽医专业教育 病理学、临​​床病理学、微生物学或实验动物医学 这将包括通过实验动物进行三个月的轮换 程序。 第一年将由兽医部资助 生物科学。 那么T32培训计划将需要三年的时间 哪些学员将在培训中完成独立研究项目 教师实验室。 没有博士学位的实习生学位将攻读博士学位。在 兽医系比较与实验病理学 生物科学。 该研究项目将侧重于使用小鼠模型 研究重大人类疾病的病理生理学。 培训内容 教师（24 名成员）专注于比较癌症方面的卓越研究 医学、传染病、免疫学和遗传学发展 改变人类疾病的小鼠模型。 所有培训教师均使用实验 在他们的工作中建立了人类疾病的小鼠模型。 24名培训师资 代表兽医生物科学领域的不同领域的研究人员， 内科、医学生化与生理学、癌症遗传学、小鼠 遗传学、外科手术、分子生物学和口腔生物学已经发展了 俄亥俄州立大学健康中心内的协作互动网络 科学中心（由七个学院组成）。 培训师资队伍 代表兽医学院、医学学院、生物科学学院、 和牙科。 OSU 综合癌症中心（包括其核心 服务）、詹姆斯癌症医院和索洛夫研究所，以及转基因 神经生物技术中心和儿童医院的核心是 俄勒冈州立大学的组织将促进研究计划和 培训师资互动。 选定的正式课程将被选择 根据学员的需求和目标。 该计划的完成将 使学员能够发展体内设计和进行所需的技能 进行实验并担任学术或工业领域的资源人员 机构利用人类小鼠模型促进研究项目 疾病。