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Comparative Pathology Core

比较病理学核心

基本信息

批准号：
9091440
负责人：
THOMAS J ROSOL
金额：
$ 18.55万
依托单位：
OHIO STATE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2004
资助国家：
美国
起止时间：
2004-09-15 至 2018-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9091440
关键词：
Antigens Authorship Autopsy Bioinformatics Biopsy Biostatistics Core Cells Collaborations Comparative Pathology Computer software Computers Confocal Microscopy Consensus Data Data Analyses Data Collection Development Doctor of Philosophy Ensure Epithelial-Stromal Communication Equipment Evaluation Evolution Experimental Designs Faculty Freezing Genetic Models Goals Grant Head Health Services Research Histology Histopathology Human Human Pathology Human Resources Image Imaging Techniques Immunohistochemistry In Situ In Situ Hybridization Instruction Laboratories Laboratory mice Leadership Lesion Link Malignant Neoplasms Mammary Neoplasms Mammary gland Manuscripts Medical Medical Oncologist Methods MicroRNAs Microscope Microscopic Microscopy Molecular Molecular Target Monitor Mus Ohio Oncologist Operative Surgical Procedures Output Paraffin Tissue Pathogenesis Pathologist Pathology Pathology Report Phase Phenotype Photography Physiological Positioning Attribute Postdoctoral Fellow Procedures Proteins Proteome Protocols documentation Quality Control Reporting Research Research Project Grants Resolution Resource Sharing Resources Sampling Services Slide Specialist Staining method Stains Supervision System Time Tissue Banks Tissue Microarray Tissue Procurements Tissue Sample Tissues Translations Ultrasonography Universities Woman Work Writing base design digital fluorescence imaging fluorescence microscope genetic analysis high standard histological stains human tissue in vivo interest laser capture microdissection malignant breast neoplasm meetings member molecular pathology mouse model outcome forecast programs protocol development research study statistics symposium tissue processing transcriptome tumor tumor microenvironment tumor progression web site

项目摘要

PROJECT SUMMARY (See instructions): The Comparative Pathology Core A will provide centralized pathology support for the three scientific projects and represents an evolution from the Mouse Pathobiology Core from the initial grant cycle. A major goal of the Comparative Pathology Core will be to provide expertise in mouse and human pathology with up-to-date proficiency in mammary gland and breast cancer pathology. In addition, a DVM, PhD postdoc in mouse pathology will perform the mouse necropsies (autopsies), cutting and processing of tissues, and evaluation of histopathology and special stains under the supervision of faculty pathologists. This will ensure excellence and continuity of service for the research projects. The Core will have 6 personnel that include three pathologists (one medical and two veterinary), medical oncologist (breast cancer specialist), a pathology fellow, and part-time histology technician. The Comparative Pathology Core is essential to ensure integration of the specific aims and experiments in relation to translation of the mouse genetic models to human breast cancer. The three pathologists and oncologist have a long track record of working together on collaborative projects, and therefore are well positioned to provide support for Core A. In addition, all three pathologists and the oncologist have collaborated with Drs. Ostrowski and Leone leading to shared authorship on manuscripts with high impact on mammary cancer microenvironment and its relationship to mammary cancer progression (1, 2). Facilities will include four necropsy rooms (including one devoted to mouse pathology), tissue processing facilities, histology laboratory with four full-time technicians (one devoted to the Core) and an automated Dako immunostainer. In Situ Molecular Pathology Core Lab with a Ventana staining system and NUANCE PLUS InForm computer-based analyses of co-expression of molecular targets, microscopy facilities including a 10-headed microscope with video output for conferences, laser capture microdissection facility and staff, tissue microarray laboratory, mouse imaging facilities including high resolution ultrasound, digital gross and microscopic photography, histomorphometry equipment including a fluorescent microscope and Image Pro Plus analysis software, and mouse surgery facilities. A SharePoint website will facilitate data transfer and sharing between the cores and project staff. These faculty and services will provide a unique resource to the research projects and significantly enhance the quality and validity of the research data.

项目概述（见说明）：