Mouse Pathobiology: Models of Human Disease

小鼠病理学：人类疾病模型

基本信息

批准号：
8207649
负责人：
THOMAS J ROSOL
金额：
$ 36.46万
依托单位：
OHIO STATE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2002
资助国家：
美国
起止时间：
2002-06-01 至 2012-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8207649
关键词：
Modeling Mus human disease

项目摘要

DESCRIPTION (provided by applicant): In this competitive renewal proposal, we seek funds to continue to provide an outstanding environment for veterinarians (D.V.M. or V.M.D.) and D.V.M./PhDs to attain specific research and conceptual skills to develop and utilize mouse models of human disease. The training program has been highly successful in establishing the program exceeding all goals of the original proposed plan. Despite having training positions cut by NCRR the program has enrolled 11 DVMs. Of the 11 trainees supported over the first 4.5 years of the program, two were awarded NIH K Awards (K08 and K01), two have matriculated and are employed in biomedical or academic positions, and 9 are completing requirements for their Ph.D. degrees of which 5 currently are funded by the T-32 training grant. All veterinarians recruited into the program have outstanding academic records and we have added new experienced training faculty. Training courses, seminars, and workshops have created specialized and focused training opportunities. Specifically, veterinarian scientists will continue to be trained in state-of-the-art techniques to systematically evaluate the pathobiology of mouse models of human disease. The training program will be coordinated through an established graduate program in the College of Veterinary Medicine and supported by a unified group of basic and clinical scientists with ongoing collaborative programs at The Ohio State University and Children's Hospital in Columbus, Ohio. Trainees will gain knowledge and skills to fully understand and evaluate pathophysiologic alterations of murine models of human disease through both didactic coursework and applied training in pathology and molecular biology. In addition, trainees will interact with our multidisciplinary faculty to identify the range of research problems that use murine models. They will acquaint themselves with the ongoing basic and clinical research studies in the laboratories of the participating faculty, and select a research problem that utilizes a murine model for endpoint evaluation. Following the selection of a preceptor and research problem, the trainee will participate in the design and performance of experiments, as well as analysis and presentation of data regarding a murine model. Therefore, trainees will acquire a broad background in molecular biology, genetics, pathology, laboratory animal medicine, as well as research design methodology, to provide trainees the skills needed to work in research teams to fulfill national needs in the development of skilled scientists in mouse pathobiology.

描述（由申请人提供）：在该竞争性更新提案中，我们寻求资金继续为兽医（D.V.M.或V.M.D.）和D.V.M./PHD提供出色的环境，以获得特定的研究和概念技能，以发展和利用人类疾病的小鼠模型。该培训计划在建立超出原始建议计划的所有目标的计划方面非常成功。尽管有NCRR裁定的培训职位，但该计划还是招募了11个DVM。在该计划的前4。5年中，在支持的11名学员中，有两名获得了NIH K奖（K08和K01），两名奖学金已入学并受雇于生物医学或学术职位，其中9名正在完成其博士学位的要求。当前5个学位由T-32培训赠款资助。招募该计划的所有兽医都具有出色的学术记录，我们增加了新的经验丰富的培训教师。培训课程，研讨会和研讨会创造了专业和专注的培训机会。具体而言，兽医科学家将继续接受最先进的技术培训，以系统地评估人类疾病小鼠模型的病理生物学。该培训计划将通过兽医学院的一项既定研究生课程进行协调，并在俄亥俄州俄亥俄州立大学和俄亥俄州哥伦布的统一基础和临床科学家组成的统一基础和临床科学家的支持下。学员将通过教学课程和病理学和分子生物学的应用培训来充分理解和评估人类疾病的鼠模型的病理生理改变。此外，学员将与我们的多学科教师互动，以确定使用鼠模型的一系列研究问题。他们将熟悉参与教师实验室中正在进行的基础和临床研究，并选择一个利用鼠模型进行终点评估的研究问题。在选择了主持人和研究问题之后，学员将参与实验的设计和性能，以及有关鼠模型的数据的分析和呈现。因此，学员将获得分子生物学，遗传学，病理学，实验室动物医学以及研究设计方法的广泛背景，以向受训者提供研究团队中工作所需的技能，以满足国家病理生物学熟练科学家的国家需求。

项目成果

期刊论文数量（23）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Mitogen-activated protein kinase phosphatase (MKP)-1 in immunology, physiology, and disease.

DOI：
10.1016/j.lfs.2011.11.017
发表时间：
2012-02-13
期刊：
LIFE SCIENCES
影响因子：
6.1
作者：
Wancket, Lyn M.;Frazier, W. Joshua;Liu, Yusen
通讯作者：
Liu, Yusen

PTHrP 1-141 and 1-86 increase in vitro bone formation.

DOI：
10.1016/j.jss.2010.02.023
发表时间：
2010-08
期刊：
The Journal of surgical research
影响因子：
0
作者：
Hildreth BE 3rd;Werbeck JL;Thudi NK;Deng X;Rosol TJ;Toribio RE
通讯作者：
Toribio RE

Interleukin-10 promotes Mycobacterium tuberculosis disease progression in CBA/J mice.

DOI：
10.4049/jimmunol.181.8.5545
发表时间：
2008-10-15
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
0
作者：
Beamer GL;Flaherty DK;Assogba BD;Stromberg P;Gonzalez-Juarrero M;de Waal Malefyt R;Vesosky B;Turner J
通讯作者：
Turner J

Quantitative measurement of anthrax toxin receptor messenger RNA in primary mononuclear phagocytes.

原代单核吞噬细胞中炭疽毒素受体信使 RNA 的定量测量。