Terahertz imaging and spectroscopy of skin for medical diagnosis

用于医学诊断的太赫兹皮肤成像和光谱

• 批准号: 2108773
• 金额: --
• 依托单位: University of Warwick
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2018
• 资助国家: 英国
• 起止时间: 2018 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2108773
• 关键词: Terahertz; imaging; spectroscopy; skin; medical

The aim of the project is to take significant steps towards the development of a THz imaging system that can be applied in a clinical setting for the imaging of patients to diagnose potential skin diseases. At present, work still needs to be done in improving the repeatability of the imaging results, for example by controlling the pressure and accounting for occlusion effects.It has already been established that THz systems are able to observe a contrast between healthy and cancerous tissue, however repeatable parameters for healthy and cancerous skin need to be defined. In particular, I the potential applications of THz in detecting early stages of skin cancer and to defining preoperatively the lateral extent of tumours below the skin will be studied. Hannah will visit and collaborate with the THz company in Cambridge, TeraView Ltd to learn from their experience of developing THz instrumentation. She will also collaborate with the international cosmetic company, Lubrizol, for advice on aspects relating to skin product research.

该项目的目的是朝着开发一种可应用于临床环境的太赫兹成像系统迈出重要的一步，为患者进行成像，以诊断潜在的皮肤病。目前，在提高成像结果的重复性方面还需要做一些工作，例如通过控制压力和考虑遮挡效应。已经建立了太赫兹系统能够观察健康和癌症组织之间的对比，但需要定义健康和癌症皮肤的可重复参数。特别是，我将研究太赫兹在检测皮肤癌早期阶段和术前确定皮下肿瘤侧方范围方面的潜在应用。汉娜将访问位于剑桥的太赫兹公司，并与TeraView有限公司合作，学习他们开发太赫兹仪器的经验。她还将与国际化妆品公司路博润合作，就与护肤品研究相关的方面提供建议。

项目成果

A Robust Protocol for In Vivo THz Skin Measurements

• DOI: 10.1007/s10762-019-00619-8
• 发表时间: 2019-09-01
• 期刊: JOURNAL OF INFRARED MILLIMETER AND TERAHERTZ WAVES
• 影响因子: 2.9
• 作者: Lindley-Hatcher, Hannah;Hernandez-Serrano, A., I;Pickwell-MacPherson, Emma
• 通讯作者: Pickwell-MacPherson, Emma

Pressure Controlled in vivo THz Measurements of Skin: Monitoring the Effects of Moisturizers

皮肤压力控制体内太赫兹测量：监测保湿剂的效果

• DOI: 10.1109/irmmw-thz.2019.8874221
• 发表时间: 2019
• 作者: Lindley H

Evaluation of in vivo THz sensing for assessing human skin hydration

• DOI: 10.1088/2515-7647/abcb71
• 发表时间: 2021-01-01
• 期刊: JOURNAL OF PHYSICS-PHOTONICS
• 影响因子: 3.8
• 作者: Lindley-Hatcher, Hannah;Hernandez-Serrano, A., I;Pickwell-MacPherson, Emma
• 通讯作者: Pickwell-MacPherson, Emma

Exploiting Complementary Terahertz Ellipsometry Configurations to Probe the Hydration and Cellular Structure of Skin In Vivo

• DOI: 10.1002/adpr.202000024
• 发表时间: 2021-01-01
• 期刊: ADVANCED PHOTONICS RESEARCH
• 作者: Chen, Xuequan;Sun, Qiushuo;Pickwell-MacPherson, Emma
• 通讯作者: Pickwell-MacPherson, Emma