Epigenetic regulation of telomere chromatin and genome stability

端粒染色质和基因组稳定性的表观遗传调控

• 批准号: nhmrc : 1123315
• 负责人: A/Pr Lee Wong
• 金额: $ 43.22万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2017
• 资助国家: 澳大利亚
• 起止时间: 2017-01-01 至 2019-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/epigenetic-regulation-telomere-genome-stability/947125
• 关键词: Epigenetic; regulation; telomere; chromatin; genome

Telomeres are structures at the end of the chromosomes that impact cell replication. 15% of cancers, called ALT cancers, show telomere instability, increased DNA damage and are frequently mutated for the ATRX gene. ALT cancers have poor prognosis, due to the limited understanding of ALT cancer activation. This study aims to create a model of ALT activation to uncover the mechanisms that control ALT tumourigenesis. This could lead to potential ALT-specific diagnostic and therapeutic tools.

端粒是染色体末端的结构，影响细胞复制。15%的癌症，称为ALT癌症，表现出端粒不稳定，增加DNA损伤，并经常发生ATRX基因突变。由于对ALT癌激活的了解有限，ALT癌预后较差。本研究旨在建立一种ALT激活模型，以揭示控制ALT肿瘤发生的机制。这可能导致潜在的ALT特异性诊断和治疗工具。