Transcription at the centromere: roles in formation, maintenance and function

着丝粒转录：在形成、维持和功能中的作用

• 批准号: nhmrc : 607317
• 负责人: A/Pr Lee Wong
• 金额: $ 36.61万
• 依托单位: Murdoch Childrens Research Institute
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2010
• 资助国家: 澳大利亚
• 起止时间: 2010-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/transcription-centromere-roles-maintenance-function/77266
• 关键词: Transcription; centromere; roles; formation; maintenance

Every human has 46 chromosomes. Chromosomes are structures that carry genes in all our cells. The centromere is an essential component of a chromosome which governs the process of cell division and separation of replicated chromosomes. Defects in centromere function cause abnormalities in cell division that in turn cause a variety of genetic diseases including cancer. We propose to investigate the role that transcription at the centromere plays in determining correct centromere function.

每个人都有46条染色体。染色体是我们所有细胞中携带基因的结构。着丝粒是染色体的重要组成部分，它控制着细胞分裂和复制染色体的分离过程。着丝粒功能缺陷导致细胞分裂异常，进而导致包括癌症在内的多种遗传疾病。我们建议调查的作用，转录在着丝粒中发挥决定正确的着丝粒功能。