Transcription at the centromere: roles in formation, maintenance and function
Transcription at the centromere: roles in formation, maintenance and function
批准号:
nhmrc : 607317
负责人:
A/Pr Lee Wong
金额:
$36.61万
依托单位国家:
澳大利亚
项目类别:
NHMRC Project Grants
财政年份:
2010
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2010-01-01 至 2012-12-31
中文摘要
每个人都有46条染色体。染色体是我们所有细胞中携带基因的结构。着丝粒是染色体的重要组成部分,它控制着细胞分裂和复制染色体的分离过程。着丝粒功能缺陷导致细胞分裂异常,进而导致包括癌症在内的多种遗传疾病。我们建议调查的作用,转录在着丝粒中发挥决定正确的着丝粒功能。
英文摘要
Every human has 46 chromosomes. Chromosomes are structures that carry genes in all our cells. The centromere is an essential component of a chromosome which governs the process of cell division and separation of replicated chromosomes. Defects in centromere function cause abnormalities in cell division that in turn cause a variety of genetic diseases including cancer. We propose to investigate the role that transcription at the centromere plays in determining correct centromere function.
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会议论文
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海外基金
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