Regulation and role of transcription at the centromere.

着丝粒转录的调节和作用。

• 批准号: nhmrc : 436920
• 负责人: A/Pr Lee Wong
• 金额: $ 49.2万
• 依托单位: Murdoch Childrens Research Institute
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2007
• 资助国家: 澳大利亚
• 起止时间: 2007-01-01 至 2009-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/regulation-role-transcription-centromere/100073
• 关键词: Regulation; role; transcription; centromere.

Every human cell has 46 chromosomes. Chromosomes are structures that carry genes in all our cells. The centromere is an essential component of a chromosome. It controls the process of cell division, and it ensures the equal division of the duplicated chromosomes. Defects in centromere function can result in various genetic diseases and development of cancers. The structure of the centromere is unique and its properties are determined by an array of proteins and other as yet unknown factors that bind to it. In our preliminary work, we have demonstrated that a novel non-protein component in the form of RNA (which are expressed products of genes) is essential for the binding of key proteins to the centromere. The presence and importance of such an RNA component has not been previously suspected and represents an exciting new mechanism that help to determine the functional and structural integrity of the centromere. In this project, we propose to study the details of this RNA and to define how this RNA-related mechanism operates to ensure the proper assembly and function of the centromere during cell division.

每个人类细胞都有46条染色体。染色体是我们所有细胞中携带基因的结构。着丝粒是染色体的重要组成部分。它控制着细胞分裂的过程，并确保复制的染色体平等分裂。着丝粒功能的缺陷可导致各种遗传疾病和癌症的发展。着丝粒的结构是独特的，它的性质是由一系列的蛋白质和其他未知的因素，绑定到it.In我们的初步工作中，我们已经证明，一种新的非蛋白质成分的形式RNA（这是基因的表达产物）是必不可少的关键蛋白质的结合到着丝粒。这种RNA成分的存在和重要性以前没有被怀疑，并代表了一种令人兴奋的新机制，有助于确定着丝粒的功能和结构完整性。在这个项目中，我们建议研究这种RNA的细节，并确定这种RNA相关的机制如何运作，以确保细胞分裂过程中着丝粒的正确组装和功能。