Function of ATRX, H3.3 and PML nuclear bodies in the regulation of telomere chromatin integrity

ATRX、H3.3和PML核体在端粒染色质完整性调节中的作用

• 批准号: nhmrc : 1031866
• 负责人: A/Pr Lee Wong
• 金额: $ 28.98万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2012
• 资助国家: 澳大利亚
• 起止时间: 2012-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/function-atrx-h33-chromatin-integrity/110826
• 关键词: Function; ATRX; H3.3; PML; nuclear

The telomere is required for protecting chromosome ends. During cell division and development, telomeres lose their repeats, exposing the chromosome ends to damage. The consequences of this damage are disease, cancer, and aging. By contrast, embryonic stem cells (ES) continually renew their telomeres and do not stop growing. ES cells thereby provide a means to unravel the molecular mechanisms of indefinite telomere renewal. Here we propose a novel mechanism that operates to control continual telomere renewal in ES cells.

端粒是保护染色体末端所必需的。在细胞分裂和发育过程中，端粒失去了它们的重复序列，使染色体末端受到损伤。这种损害的后果是疾病、癌症和衰老。相比之下，胚胎干细胞（ES）不断更新其端粒，并且不会停止生长。因此，ES细胞提供了一种手段来解开端粒无限更新的分子机制。在这里，我们提出了一种新的机制，操作来控制连续的端粒更新ES细胞。