Histone H3.3 dynamics at the telomere in pluripotent embryonic stem cells

多能胚胎干细胞端粒的组蛋白 H3.3 动态

• 批准号: nhmrc : 491242
• 负责人: A/Pr Lee Wong
• 金额: $ 38.14万
• 依托单位: Murdoch Childrens Research Institute
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2008
• 资助国家: 澳大利亚
• 起止时间: 2008-01-01 至 2010-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/histone-h33-dynamics-stem-cells/76630
• 关键词: Histone; H3.3; dynamics; telomere; pluripotent

The telomere is required for the protection of the chromosome ends. Telomere loses its repeat during each cell division, so telomere shorthening is one of the mechanisms underlying organismal aging as critically short telomeres induce chromosome instability and cell death. Defective telomeres can also result in genetic diseases and development of cancers. Here, we propose to study the mechanism that operates to ensure continual telomere renewal without senescence in embryonic stem cells.

端粒是保护染色体末端所必需的。端粒在每次细胞分裂过程中失去其重复序列，因此端粒缩短是生物体衰老的潜在机制之一，因为非常短的端粒会导致染色体不稳定和细胞死亡。端粒缺陷也可能导致遗传疾病和癌症的发展。在这里，我们建议研究的机制，以确保持续的端粒更新而不衰老的胚胎干细胞。