Essential roles of RNA polymerase II transcription and DNA damage response pathway in the maintenance of centromere chromatin assembly

RNA聚合酶II转录和DNA损伤反应途径在维持着丝粒染色质组装中的重要作用

• 批准号: nhmrc : 1043881
• 负责人: A/Pr Lee Wong
• 金额: $ 40.09万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2013
• 资助国家: 澳大利亚
• 起止时间: 2013-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/essential-roles-rna-chromatin-assembly/111610
• 关键词: Essential; roles; RNA; polymerase; II

A centromere is a region of DNA typically found near the middle of a chromosome where two identical sister chromatids come in contact. It is involved in cell division as the point of attachment to the mitotic spindle. Defective centromeres can result in genome instability, infertility and development of cancers. This work involves a study into how the identity of a centromere is maintained and inherited after each cell division. This has significant implication in the understanding of cell growth and cancer development.

着丝粒是 DNA 的一个区域，通常位于染色体中部附近，两条相同的姐妹染色单体在此接触。它作为有丝分裂纺锤体的附着点参与细胞分裂。有缺陷的着丝粒会导致基因组不稳定、不孕和癌症的发生。这项工作涉及研究每次细胞分裂后着丝粒的身份如何维持和遗传。这对于理解细胞生长和癌症发展具有重要意义。