Essential roles of RNA polymerase II transcription and DNA damage response pathway in the maintenance of centromere chromatin assembly
Essential roles of RNA polymerase II transcription and DNA damage response pathway in the maintenance of centromere chromatin assembly
批准号:
nhmrc : 1043881
负责人:
A/Pr Lee Wong
金额:
$40.09万
依托单位:
依托单位国家:
澳大利亚
项目类别:
Project Grants
财政年份:
2013
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2013-01-01 至 2015-12-31
中文摘要
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英文摘要
A centromere is a region of DNA typically found near the middle of a chromosome where two identical sister chromatids come in contact. It is involved in cell division as the point of attachment to the mitotic spindle. Defective centromeres can result in genome instability, infertility and development of cancers. This work involves a study into how the identity of a centromere is maintained and inherited after each cell division. This has significant implication in the understanding of cell growth and cancer development.
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批准号:nhmrc : GNT1123315
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项目类别:Project Grants
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依托单位:
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批准号:nhmrc : 1031866
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项目类别:Project Grants
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资助金额:$28.98万
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财政年份:2012
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依托单位:
Epigenetic regulation of core centromere CENP-A chromatin integrity
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批准号:nhmrc : 1031872
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项目类别:Project Grants
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资助金额:$21.22万
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财政年份:2012
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依托单位:
Role of the histone variant H3.3 in germ cell development
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批准号:nhmrc : 1002316
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财政年份:2011
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依托单位:
Transcription at the centromere: roles in formation, maintenance and function
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项目类别:NHMRC Project Grants
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财政年份:2010
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依托单位:
Mechanisms for the establishment and regulation of centromere and telomere chromatin
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依托单位:
Changes to the structure of the centromere during differentiation and cancer progression
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批准号:nhmrc : 546454
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资助金额:$34.09万
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财政年份:2009
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依托单位:
Histone H3.3 dynamics at the telomere in pluripotent embryonic stem cells
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批准号:nhmrc : 491242
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项目类别:NHMRC Project Grants
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资助金额:$38.14万
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财政年份:2008
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负责人:A/Pr Lee Wong
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依托单位:
Regulation and role of transcription at the centromere.
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资助金额:$49.2万
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财政年份:2007
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负责人:A/Pr Lee Wong
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依托单位:
HUMAN CHROMATIN ROADMAP AND FUNCTIONAL PLASTICITY
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批准号:nhmrc : 384429
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资助金额:$30.49万
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依托单位:
Development and characterisation of human engineered chromosome with potential therapeutic potential
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资助金额:$26.02万
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财政年份:2006
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负责人:A/Pr Lee Wong
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依托单位:
Role of DNA methylation and non-coding RNA in human centromere function
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资助金额:$33.27万
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依托单位:
Development of therapeutically useful Human Artificial Chromosomes for gene delivery and optimal gene expression
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资助金额:$33.14万
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依托单位:
海外基金