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Essential roles of RNA polymerase II transcription and DNA damage response pathway in the maintenance of centromere chromatin assembly

Essential roles of RNA polymerase II transcription and DNA damage response pathway in the maintenance of centromere chromatin assembly
RNA聚合酶II转录和DNA损伤反应途径在维持着丝粒染色质组装中的重要作用
批准号:
nhmrc : 1043881
负责人:
A/Pr Lee Wong
金额:
$40.09万
依托单位:
依托单位国家:
澳大利亚
项目类别:
Project Grants
财政年份:
2013
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2013-01-01 至 2015-12-31

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中文摘要
翻译
着丝粒是DNA的一个区域,通常发现在染色体中央附近,两个相同的姐妹染色单体在这里接触。它作为有丝分裂纺锤体的连接点参与细胞分裂。着丝粒缺陷可能导致基因组不稳定、不孕和癌症的发展。这项工作涉及一项研究,即着丝粒的身份是如何在每次细胞分裂后保持和遗传的。这对于理解细胞生长和癌症的发展具有重要意义。
英文摘要
A centromere is a region of DNA typically found near the middle of a chromosome where two identical sister chromatids come in contact. It is involved in cell division as the point of attachment to the mitotic spindle. Defective centromeres can result in genome instability, infertility and development of cancers. This work involves a study into how the identity of a centromere is maintained and inherited after each cell division. This has significant implication in the understanding of cell growth and cancer development.
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Epigenetic regulation of telomere chromatin and genome stability
  • 批准号:
    nhmrc : GNT1123315
  • 项目类别:
    Project Grants
  • 资助金额:
    $63.34万
  • 财政年份:
    2017
  • 负责人:
    A/Pr Lee Wong
  • 依托单位:
Epigenetic regulation of telomere chromatin and genome stability
  • 批准号:
    nhmrc : 1123315
  • 项目类别:
    Project Grants
  • 资助金额:
    $43.22万
  • 财政年份:
    2017
  • 负责人:
    A/Pr Lee Wong
  • 依托单位:
Function of ATRX, H3.3 and PML nuclear bodies in the regulation of telomere chromatin integrity
  • 批准号:
    nhmrc : 1031866
  • 项目类别:
    Project Grants
  • 资助金额:
    $28.98万
  • 财政年份:
    2012
  • 负责人:
    A/Pr Lee Wong
  • 依托单位:
Epigenetic regulation of core centromere CENP-A chromatin integrity
  • 批准号:
    nhmrc : 1031872
  • 项目类别:
    Project Grants
  • 资助金额:
    $21.22万
  • 财政年份:
    2012
  • 负责人:
    A/Pr Lee Wong
  • 依托单位:
海外基金