Negative Cognition Depression: Etiology and Course

描述(由申请人提供)：此竞争续展是 提交相同申请的两个站点合作研究补助金 同时由坦普尔大学的劳伦·B·科洛博士主持。先前的研究就是这样做的 没有为绝望理论和贝克理论提供充分的检验 (BT)抑郁症，可能对这些认知理论具有误导性。 有效性。因此，该项目的总体目标是提供更多 对HT和BT关于抑郁症病因和疾病预测的有力检验 对绝望抑郁亚型的验证。为此，一个大型的 规模，两个地点都进行了5.5年的前瞻性研究。最初 非抑郁、非精神病SS(n=349)，处于高或低水平 抑郁的认知风险被前瞻性地跟随着独立和 对有压力的生活事件进行盲目的自我报告和面试评估， 认知、社会支持、应对和精神状态/症状 预测抑郁症的发病和随后的复发。家族性和 抑郁症认知易感性的发育起源也是 接受检查，包括对高风险和低风险父母(n=335)的评估 党卫军。在这一更新中，第一个首集的微分预报器与 抑郁症，增加高危SS的复原力并促进 低危SS人群中的抑郁、导致抑郁的因素及适度变化 认知脆弱性和认知脆弱性的不同模型--压力 双方的关系也受到了调查。本项目的贡献在于：1) 对部分情绪的病因和病程的科学认识 障碍；2)更有效的抑郁障碍的病史；3)和 认知脆弱性的起源和延续/变化的理解 对抑郁的认识；4)对促进抗抑郁的因素的理解 抑郁症；5)治疗和预防干预措施的发展 抑郁症。

DESCRIPTION (provided by applicant): This competing continuation is part of a 2-site collaborative research grant with an identical application submitted concurrently by Dr. Lauren B. Alloy at Temple University. Prior research did not provide an adequate test of the hopelessness theory (HT) and Beck's theory (BT) of depression and may have been misleading about those cognitive theories' validity. Thus, the overarching goal of this project is to provide a more powerful test of HT's and BT's predictions about the etiology of depression and a validation of the Hopelessness Depression subtype. To this end, a large scale, 5.5-year prospective study was conducted at both sites. Initially nondepressed, non-psychopathological Ss (n=349) who were at either high or low cognitive risk for depression were followed prospectively with independent and blind self-report and interview assessments of stressful life events, cognitions, social support, coping, and psychiatric status/symptoms in order to predict onsets and subsequent recurrences of depression. Familial and developmental origins of cognitive vulnerability to depression also were examined, including assessment of the parents (n=335) of high-risk and low-risk Ss. In this renewal, differential predictors of first onsets vs. recurrences of depression, factors that increase resilience among high-risk Ss and promote depression among low-risk Ss, factors that contribute to and moderate change in cognitive vulnerability, and different models of cognitive vulnerability-stress relations also were investigated. This project contributes to: 1) the scientific understanding of the etiology and course of a subset of the mood disorders; 2) a more valid nosologv of the depressive disorders; 3) an understanding of the origins and continuity/change of cognitive vulnerability to depression; 4) an understanding of factors that promote resilience to depression; and 5) the development of interventions for treating and preventing depression.