Exacerbation of Atherosclerosis

描述（由申请人提供）：Atherecom是负责人 心肌梗死和脑梗死的发病机制， 动脉粥样硬化的有效治疗仍然是可用的。识别 病因和了解致病机制 动脉粥样硬化可以为开发有效的策略提供信息， 预防和/或控制心血管疾病发病机制。两 流行病学调查和动物模型研究表明，C. 肺炎感染与动脉粥样硬化的关系本提案的目标 进一步评价C.动脉粥样硬化中肺炎感染 在小鼠模型系统中，并使用这种动物系统来了解 C.机制肺炎动脉粥样硬化通过测试感染/ 炎症反应假说具体来说，炎症和炎症反应的作用 反应和脂蛋白氧化。肺炎加重 将评估动脉粥样硬化。这些研究可以提供必要的 关于设计预防和控制C的有效方法的信息。 肺炎加重了动脉粥样硬化

DESCRIPTION (provided by the applicant): Atherosclerosis is the principal contributor to the pathogenesis of myocardial and cerebral infarction, and no effective treatment is yet available for atherosclerosis. Identifying the etiological causes and understanding the pathogenic mechanisms of atherosclerosis may provide information for developing efficient strategies for preventing and/or controlling cardiovascular disease pathogenesis. Both epidemiological investigations and animal model studies have linked C. pneumoniae infection to atherosclerosis. The objectives of the present proposal are to further evaluate the role of C. pneumoniae infection in atherosclerosis in a mouse model system and to use this animal system to understand the mechanisms of C. pneumoniae atherogenesis by testing an infection / inflammatory response hypothesis. Specifically, the roles of both inflammatory responses and lipoprotein oxidation in C. pneumoniae exacerbation of atherosclerosis will be evaluated. These studies may provide the essential information on designing effective approaches for preventing and controlling C. pneumoniae-exacerbated atherosclerosis.