Chlamydial Manipulation of Host Apoptosis

衣原体操纵宿主细胞凋亡

• 批准号: 7031922
• 负责人: GUANGMING ZHONG
• 金额: $ 32.85万
• 依托单位: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-02-15 至 2011-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7031922
• 关键词: Chlamydiaceae; apoptosis; cofactor; infection

DESCRIPTION (provided by applicant): --Mechanisms of Chlamydial Manipulation of Host Cell Apoptosis-- Chlamydial infection in humans imposes a major health problem in both developing and developed nations. Urogenital tract infection with C. trachomatis species is a leading cause of sexually transmitted bacterial diseases and is also linked to certain type of cervical carcinoma while respiratory infection with C. pneumoniae species is associated with atherosclerosis, a major vascular condition for cardio-cerebral fatality. Although the species C. psittaci is primarily an animal pathogen, humans are also susceptible to C. psittaci infection, developing life-threatening pneumonia. Since humans can acquire infection via aerosolized animal feces that are contaminated with C. psittaci organisms, CDC has once listed C. psittaci as a category B agent for biodefense. These chlamydia-induced or -associated pathologies are largely due to Chlamydial ability to either productively replicate or to achieve a long-term persistence within a cytoplasmic vacuole of eukaryotic cells, which are aided by the Chlamydial unique intracellular biphasic life cycle and the Chlamydial ability to evade host defense. The current proposal is designed to understand how chlamydia evades a very important host defense effector mechanism-apoptosis. We have previously demonstrated that chlamydia possesses a potent anti-apoptotic activity, which may contribute to the Chlamydial ability to survive in the infected hosts for long periods of time. By identifying the molecule(s) responsible for the Chlamydial anti-apoptotic activity and understanding how the anti-apoptotic molecules work as proposed in the current project, we may be able to develop reagents/approaches for blocking the Chlamydial anti-apoptotic activity and preventing chlamydia-induced pathologies.

描述（由申请人提供）：-衣原体操纵宿主细胞凋亡的机制- 人类衣原体感染在发展中国家和发达国家都是一个主要的健康问题。泌尿生殖道C.沙眼衣原体是性传播细菌疾病的主要原因，也与某些类型的宫颈癌有关，而呼吸道感染C。肺炎菌与动脉粥样硬化有关，动脉粥样硬化是导致心脑血管死亡的主要血管疾病。虽然C.鹦鹉热主要是一种动物病原体，人类也容易感染鹦鹉热。鹦鹉热感染，发展成危及生命的肺炎。由于人类可以通过被C.鹦鹉热生物，CDC曾将C.作为生物防御的B类药剂。这些衣原体诱导的或相关的病理主要是由于衣原体的能力，要么生产性复制或实现长期持久的真核细胞的胞质空泡内，这是由衣原体独特的细胞内双相生命周期和衣原体的能力，以逃避宿主防御的帮助。目前的建议是为了了解衣原体如何逃避一个非常重要的宿主防御效应机制-细胞凋亡。我们以前已经证明，衣原体具有有效的抗凋亡活性，这可能有助于衣原体的能力，在感染的主机中存活很长一段时间。通过鉴定负责衣原体抗凋亡活性的分子并了解抗凋亡分子如何如当前项目中所提出的那样工作，我们可能能够开发用于阻断衣原体抗凋亡活性和预防衣原体诱导的病理的试剂/方法。