Single Shot OCT

单次OCT

• 批准号: 7108289
• 负责人: DANIEL X HAMMER
• 金额: $ 10万
• 依托单位: PHYSICAL SCIENCES, INC
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-09-10 至 2008-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7108289
• 关键词: arm; bioimaging /biomedical imaging; diabetic retinopathy; diagnosis; early diagnosis; eye; glaucoma; human; interferometry; lead; lens; lighting; macular degeneration; noise; optical tomography; retina; sectioning

DESCRIPTION (provided by applicant): Spectral domain optical coherence tomography (SDOCT) has revolutionized the methodology of low coherence interferometry for biomedical imaging applications. SDOCT detects signals from every range gate in a focal volume simultaneously, allowing ultra-high acquisition speeds, increased signal-to-noise ratio, and improved phase stability. Like conventional OCT more than 10 years ago, SDOCT has been demonstrated in vivo first, and hold the most promise for disease diagnosis in the field of ophthalmology. Physical Sciences Inc. proposes to extend the dimensionality of SDOCT with the creation and development of a single-shot optical coherence tomographer (SSOCT). SSOCT will capture full two-dimensional (2D) cross-sections simultaneously with an imaging spectrograph. It will allow full three-dimensional (3D) depth-resolved maps to be collected in a fraction of a second. Moreover, SSOCT reduces the complexity of the front-end transverse scan engine and may lead to the development of more portable instruments. In ophthalmology, the pernicious effects of eye motion will be rendered inconsequential and new functional and pump-probe imaging techniques can finally reach fruition. SSOCT, built upon the foundation of SDOCT and OCT, has the potential for early detection of a wide range of retinal pathologies, from glaucoma to macular degeneration. Relevance of research to public health: The proposed research will lead to earlier and improved diagnosis of retinal diseases such as glaucoma, diabetic retinopathy and age-related macular degeneration. In addition, the developed instrument and the principles upon which it is based may be used to image other disease types throughout the human body.

描述（由申请人提供）：谱域光学相干断层扫描（SDOCT）彻底改变了用于生物医学成像应用的低相干干涉测量方法。SDOCT可同时检测来自焦区中每个距离门的信号，从而实现超高采集速度、更高的信噪比和更高的相位稳定性。与10多年前的传统OCT一样，SDOCT首先在体内得到了证实，并在眼科领域的疾病诊断中最有希望。物理科学公司建议扩展SDOCT的维度，创建和开发单次光学相干断层扫描仪（SSOCT）。SSOCT将与成像光谱仪同时捕获完整的二维（2D）横截面。它将允许在几分之一秒内收集完整的三维（3D）深度分辨地图。此外，SSOCT降低了前端横向扫描引擎的复杂性，并可能导致开发更便携的仪器。在眼科学中，眼球运动的有害影响将变得无关紧要，新的功能性和泵浦探测成像技术最终将取得成果。SSOCT建立在SDOCT和OCT的基础上，具有早期检测从青光眼到黄斑变性的各种视网膜病变的潜力。研究与公共卫生的相关性：拟议的研究将导致早期和改善视网膜疾病的诊断，如青光眼，糖尿病视网膜病变和年龄相关性黄斑变性。此外，所开发的仪器及其所基于的原理可用于对整个人体的其他疾病类型进行成像。